SEC15 Rab GTPase-binding exocyst subunit SEC15 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEC15
Official Full Name: Rab GTPase-binding exocyst subunit SEC15
Primary source: SGD:S000003202
Locus tag: YGL233W
See related: AllianceGenome:SGD:S000003202; FungiDB:YGL233W; VEuPathDB:YGL233W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables small GTPase binding activity. Involved in Golgi to plasma membrane transport and exocytosis. Located in cellular bud neck; cellular bud tip; and incipient cellular bud site. Part of exocyst. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to several human genes including EXOC6B (exocyst complex component 6B). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SEC15 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (59122..61854)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified the Sec15-binding region on Myo2 and residues on Sec15 required for interaction with Myo2. That Myo2 interacts with Sec15 uncovers additional roles for the exocyst as an adaptor for molecular motors.
Title: Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle tethering involved in exocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IDA Inferred from Direct Assay more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in prospore membrane	HDA more info	PubMed

General protein information

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Preferred Names: Rab GTPase-binding exocyst subunit SEC15

NP_011281.1

Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

59122..61854

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181099.1 → NP_011281.1 TPA: Rab GTPase-binding exocyst subunit SEC15 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011281.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVA1, P22224

UniProtKB/TrEMBL

A6ZTV7, B3LHS6, N1P240

Conserved Domains (1) summary

pfam04091
Location:521 → 864

Sec15; Exocyst complex subunit Sec15-like