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Pex11a peroxisomal biogenesis factor 11 alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 85249, updated on 27-Nov-2024

Summary

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Official Symbol
Pex11aprovided by RGD
Official Full Name
peroxisomal biogenesis factor 11 alphaprovided by RGD
Primary source
RGD:619842
See related
EnsemblRapid:ENSRNOG00000015003 AllianceGenome:RGD:619842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pmp26p
Summary
Predicted to enable protein homodimerization activity. Involved in peroxisome membrane biogenesis. Located in peroxisomal membrane. Orthologous to human PEX11A (peroxisomal biogenesis factor 11 alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 59.0), Liver (RPKM 33.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pex11a in Genome Data Viewer
Location:
1q31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143089410..143096491, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (133680091..133687172, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141474189..141481270, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 7 Neighboring gene uncharacterized LOC120099868 Neighboring gene perilipin 1 Neighboring gene WD repeat domain 93 Neighboring gene small nuclear ribonucleoprotein polypeptide E like 2 Neighboring gene mesoderm posterior bHLH transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11. Abe I, et al. FEBS Lett, 1998 Jul 24. PMID 9714566
  2. Peroxisome biogenesis: involvement of ARF and coatomer. Passreiter M, et al. J Cell Biol, 1998 Apr 20. PMID 9548716, Free PMC Article
  3. The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p- and Pex16p-dependent pathway. Matsuzaki T, et al. J Cell Biol, 2008 Dec 29. PMID 19114594, Free PMC Article
  4. Targeting of hFis1 to peroxisomes is mediated by Pex19p. Delille HK, et al. J Biol Chem, 2008 Nov 7. PMID 18782765, Free PMC Article
  5. Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. Schrader M, et al. J Biol Chem, 1998 Nov 6. PMID 9792670

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome fission ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome membrane biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peroxisome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in peroxisome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of peroxisome size ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal membrane protein 11A
Names
28 kDa peroxisomal integral membrane protein
PEX11-alpha
PEX11alpha
PMP28
peroxin-11A
peroxisomal biogenesis factor 11A
peroxisomal coatomer receptor
peroxisomal membrane protein 26
peroxisomal membrane protein Pmp26p (Peroxin-11)
pex11palpha
protein PEX11 homolog alpha
rnPEX11p

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053487.2 → NP_445939.1  peroxisomal membrane protein 11A

    See identical proteins and their annotated locations for NP_445939.1

    Status: VALIDATED

    Source sequence(s)
    AJ224120, BC061835, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O70597, Q6P749
    UniProtKB/TrEMBL
    A6JC69
    Related
    ENSRNOP00000020229.4, ENSRNOT00000020229.8
    Conserved Domains (1) summary
    pfam05648
    Location:1 → 237
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    143089410..143096491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092913.2 → XP_038948841.1  peroxisomal membrane protein 11A isoform X1

    Conserved Domains (1) summary
    pfam05648
    Location:2 → 117
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70597.1 GenPept UniProtKB/Swiss-Prot:O70597

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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