U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

POP7 ribonuclease P/MRP protein subunit POP7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852465, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
POP7
Official Full Name
ribonuclease P/MRP protein subunit POP7
Primary source
SGD:S000000371
Locus tag
YBR167C
See related
AllianceGenome:SGD:S000000371; FungiDB:YBR167C; VEuPathDB:YBR167C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPP2
Summary
Enables RNA binding activity. Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Part of nucleolar ribonuclease P complex; ribonuclease MRP complex; and telomerase holoenzyme complex. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See POP7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (571468..571890, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ubs1p Neighboring gene prephenate dehydrogenase (NADP(+)) Neighboring gene Pex32p Neighboring gene adenyl-nucleotide exchange factor SSE2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain. Perederina A, et al. EMBO J, 2010 Feb 17. PMID 20075859, Free PMC Article
  2. Footprinting analysis of interactions between the largest eukaryotic RNase P/MRP protein Pop1 and RNase P/MRP RNA components. Fagerlund RD, et al. RNA, 2015 Sep. PMID 26135751, Free PMC Article
  3. Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae. Stolc V, et al. Proc Natl Acad Sci U S A, 1998 Jun 9. PMID 9618478, Free PMC Article
  4. Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7. Perederina A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jan 1. PMID 20057077, Free PMC Article
  5. Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P. Perederina A, et al. RNA Biol, 2023 Jan. PMID 37074161, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study reports that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the telomerase holoenzyme.
    Title: Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP.
  2. Crystal of Pop6 (18.2 kDa) and Pop7 (15.8 kDa) were obtained. They belonged to space group P4(2)22 (unit-cell parameters a = b = 127.2, c = 76.8 A, alpha = beta = gamma = 90 degrees ) and diffracted to 3.25 A resolution
    Title: Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7.
  3. Footprint analysis of the interaction between the Pop6/7 heterodimer and the RNase mitochondrial RNA-processing RNA, combined with gel mobility assays, demonstrates that the Pop6/7 complex binds to a conserved region of the P3 domain.
    Title: Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of the yeast RNase MRP and RNase P RNAs.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribonuclease MRP activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonuclease MRP activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ribonuclease MRP activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonuclease P activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribonuclease P activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intronic box C/D snoRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intronic box C/D snoRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA 5'-leader removal IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleolar ribonuclease P complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleolar ribonuclease P complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonuclease MRP complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of ribonuclease MRP complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ribonuclease P/MRP protein subunit POP7
NP_009726.3
  • Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    571468..571890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178515.3 → NP_009726.3  TPA: ribonuclease P/MRP protein subunit POP7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009726.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQG3, E9P8X7, P38291
    UniProtKB/TrEMBL
    A6ZLB0, B3LMZ1, B5VEC3, C7GUI2, D3UER2, G2W9H0, N1P9J0
    Conserved Domains (1) summary
    pfam12328
    Location:28 → 137
    Rpp20; Rpp20 subunit of nuclear RNase MRP and P
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38291.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools