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EXO5 Exo5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852461, updated on 4-Jan-2025

Summary

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Official Symbol
EXO5
Official Full Name
Exo5p
Primary source
SGD:S000000367
Locus tag
YBR163W
See related
AllianceGenome:SGD:S000000367; FungiDB:YBR163W; VEuPathDB:YBR163W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DEM1
Summary
Enables single-stranded DNA 5'-3' DNA exonuclease activity. Involved in mitochondrial genome maintenance. Located in mitochondrion. Orthologous to human EXO5 (exonuclease 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See EXO5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (565723..567480)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Tos1p Neighboring gene Ysy6p Neighboring gene Arf family GTPase ARL1 Neighboring gene Ubs1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exonuclease V from Saccharomyces cerevisiae. A 5'----3'-deoxyribonuclease that produces dinucleotides in a sequential fashion. Burgers PM, et al. J Biol Chem, 1988 Jun 15. PMID 3286646
  2. Detection of eQTL modules mediated by activity levels of transcription factors. Sun W, et al. Bioinformatics, 2007 Sep 1. PMID 17599927
  3. Yeast exonuclease 5 is essential for mitochondrial genome maintenance. Burgers PM, et al. Mol Cell Biol, 2010 Mar. PMID 20086101, Free PMC Article
  4. Scan statistics analysis for detection of introns in time-course tiling array data. Reiner-Benaim A, et al. Stat Appl Genet Mol Biol, 2014 Apr 1. PMID 24572987
  5. Human exonuclease 5 is a novel sliding exonuclease required for genome stability. Sparks JL, et al. J Biol Chem, 2012 Dec 14. PMID 23095756, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA 5'-3' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Exo5p
NP_009722.3
  • Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    565723..567480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178511.3 → NP_009722.3  TPA: Exo5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009722.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQF9, P38289
    UniProtKB/TrEMBL
    G2W9G6, N1P8B3
    Conserved Domains (1) summary
    pfam09810
    Location:126 → 560
    Exo5; Exonuclease V - a 5' deoxyribonuclease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38289.1

Gene LinkOut

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