U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OPY1 Opy1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852426, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
OPY1
Official Full Name
Opy1p
Primary source
SGD:S000000333
Locus tag
YBR129C
See related
AllianceGenome:SGD:S000000333; FungiDB:YBR129C; VEuPathDB:YBR129C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See OPY1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (494353..495339, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit B Neighboring gene Atg14p Neighboring gene She3p Neighboring gene Ccz1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis. Ling Y, et al. EMBO J, 2012 Jun 29. PMID 22562153, Free PMC Article
  2. Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. Szentpetery Z, et al. BMC Cell Biol, 2009 Sep 21. PMID 19769794, Free PMC Article
  3. A PhotoClick cholesterol-based quantitative proteomics screen for cytoplasmic sterol-binding proteins in Saccharomyces cerevisiae. Chauhan N, et al. Yeast, 2020 Jan. PMID 31758572
  4. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Edwards MC, et al. Genetics, 1997 Nov. PMID 9383053, Free PMC Article
  5. A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Gallego O, et al. Mol Syst Biol, 2010 Nov 30. PMID 21119626, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Opy1p
NP_009687.1
  • hypothetical protein; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    494353..495339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178477.1 → NP_009687.1  TPA: Opy1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009687.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQC6, P38271
    UniProtKB/TrEMBL
    A6ZL73, B3LN27, B5VE89, C7GY12, D3UEM2, G2W9D3, N1PAT4
    Conserved Domains (1) summary
    cl17171
    Location:214 → 315
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38271.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous