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SPT7 SAGA histone acetyltransferase complex subunit SPT7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852373, updated on 4-Jan-2025

Summary

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Official Symbol
SPT7
Official Full Name
SAGA histone acetyltransferase complex subunit SPT7
Primary source
SGD:S000000285
Locus tag
YBR081C
See related
AllianceGenome:SGD:S000000285; FungiDB:YBR081C; VEuPathDB:YBR081C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GIT2
Summary
Enables structural molecule activity. Involved in chromatin organization; conjugation with cellular fusion; and protein-containing complex assembly. Located in mitochondrion. Part of SAGA complex and SLIK (SAGA-like) complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SPT7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (401253..405251, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 core subunit a Neighboring gene AAA family ATPase SEC18 Neighboring gene tRNA-Arg Neighboring gene tRNA-Asp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo. Gansheroff LJ, et al. Genetics, 1995 Feb. PMID 7713415, Free PMC Article
  2. Involvement of Spt7p in vacuolar polyphosphate level of Saccharomyces cerevisiae. Nishimura K, et al. Biochem Biophys Res Commun, 1999 Apr 21. PMID 10208869
  3. Cross-talk between histone H3 tails produces cooperative nucleosome acetylation. Li S, et al. Proc Natl Acad Sci U S A, 2008 Nov 25. PMID 19004784, Free PMC Article
  4. Transcription of some PHO genes in Saccharomyces cerevisiae is regulated by spt7p. Nishimura K, et al. Yeast, 1999 Dec. PMID 10590460
  5. Three genes are required for trans-activation of Ty transcription in yeast. Winston F, et al. Genetics, 1987 Apr. PMID 3034719, Free PMC Article

See all (177) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAGA-CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity.
    Title: SAGA-CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity.
  2. SAGA-TBP binding involves a network of interactions between subunits Spt3, Spt8, Spt20, and Spt7.
    Title: Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.
  3. truncation of Spt7 occurs early in the biosynthesis of distinct Spt7 containing complexes rather than being a dynamic process linked to the action of the SAGA complex in transcriptional regulation
    Title: C-terminal processing of yeast Spt7 occurs in the absence of functional SAGA complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural molecule activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural molecule activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IEA
Inferred from Electronic Annotation
more info
  
part_of SLIK (SAGA-like) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SAGA histone acetyltransferase complex subunit SPT7
NP_009637.1
  • Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    401253..405251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178429.1 → NP_009637.1  TPA: SAGA histone acetyltransferase complex subunit SPT7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009637.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ80, P35177
    UniProtKB/TrEMBL
    C7GQJ4, N1P834
    Conserved Domains (1) summary
    COG5076
    Location:282 → 680
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35177.1

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