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REG2 protein phosphatase regulator REG2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852340, updated on 4-Jan-2025

Summary

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Official Symbol
REG2
Official Full Name
protein phosphatase regulator REG2
Primary source
SGD:S000000254
Locus tag
YBR050C
See related
AllianceGenome:SGD:S000000254; FungiDB:YBR050C; VEuPathDB:YBR050C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein phosphatase regulator activity. Involved in cellular response to glucose stimulus. Acts upstream of or within regulation of cellular response to glucose starvation. Part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See REG2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (337183..338199, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S11B Neighboring gene DNA-binding protein REB1 Neighboring gene flavodoxin-like fold family protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of SNF4 and deletions of REG1- and REG2-enhanced maltose metabolism and leavening ability of baker's yeast in lean dough. Lin X, et al. J Ind Microbiol Biotechnol, 2018 Sep. PMID 29936578
  2. The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Frederick DL, et al. Mol Cell Biol, 1996 Jun. PMID 8649403, Free PMC Article
  3. Springing into Action: Reg2 Negatively Regulates Snf1 Protein Kinase and Facilitates Recovery from Prolonged Glucose Starvation in Saccharomyces cerevisiae. Maziarz M, et al. Appl Environ Microbiol, 2016 Jul 1. PMID 27107116, Free PMC Article
  4. Protein phosphatase type-1 regulatory subunits Reg1p and Reg2p act as signal transducers in the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae. Jiang H, et al. Mol Gen Genet, 2000 Apr. PMID 10821175
  5. Glc8 is a glucose-repressible activator of Glc7 protein phosphatase-1. Nigavekar SS, et al. Arch Biochem Biophys, 2002 Aug 1. PMID 12127071

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors present evidence that Reg2 contributes to Snf1 Thr210 dephosphorylation.
    Title: Springing into Action: Reg2 Negatively Regulates Snf1 Protein Kinase and Facilitates Recovery from Prolonged Glucose Starvation in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein phosphatase type 1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase regulator REG2
NP_009606.1
  • Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    337183..338199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178398.1 → NP_009606.1  TPA: protein phosphatase regulator REG2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009606.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ50, P38232
    UniProtKB/TrEMBL
    G2W956, N1P9D4
    Conserved Domains (1) summary
    pfam08550
    Location:133 → 153
    DUF1752; Fungal protein of unknown function (DUF1752)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38232.1

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