PEP1 type I sorting receptor [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PEP1
Official Full Name: type I sorting receptor
Primary source: SGD:S000000113
Locus tag: YBL017C
See related: AllianceGenome:SGD:S000000113; FungiDB:YBL017C; VEuPathDB:YBL017C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: VPS10; VPT1
Summary: Enables signal sequence binding activity. Involved in mitophagy; pexophagy; and protein targeting to vacuole. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Myosin V-mediated transport of Snc1 and Vps10 toward the trans-Golgi network.
Title: Myosin V-mediated transport of Snc1 and Vps10 toward the trans-Golgi network.
Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner.
Title: Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables signal sequence binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_009536.1

Type I transmembrane sorting receptor for multiple vacuolar hydrolases; plays role in post-ER quality control in the Golgi, involved in protein targeting from the endoplasmic reticulum to the vacuole for degradation; cycles between late-Golgi and prevacuolar endosome-like compartments; targeted to vacuole via AP-3 pathway

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The following sections contain reference sequences that belong to a specific genome build. Explain