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GPI17 GPI-anchor transamidase GPI17 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852044, updated on 4-Jan-2025

Summary

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Official Symbol
GPI17
Official Full Name
GPI-anchor transamidase GPI17
Primary source
SGD:S000002842
Locus tag
YDR434W
See related
AllianceGenome:SGD:S000002842; FungiDB:YDR434W; VEuPathDB:YDR434W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum and nuclear inner membrane. Part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 95. Orthologous to human PIGS (phosphatidylinositol glycan anchor biosynthesis class S). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GPI17 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1331237..1332841)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene pitrilysin family metalloprotease Neighboring gene mRNA-binding protein NPL3 Neighboring gene leucine carboxy methyltransferase Neighboring gene salt homeostasis regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and crystallization of yeast glycosylphosphatidylinositol transamidase subunit PIG-S (PIG-S(71-467)). Kamariah N, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Aug 1. PMID 21821889, Free PMC Article
  2. Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast. Toh YK, et al. J Struct Biol, 2011 Feb. PMID 21134462
  3. Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation. Grimme SJ, et al. Mol Biol Cell, 2004 Jun. PMID 15075373, Free PMC Article
  4. Gpi17p does not stably interact with other subunits of glycosylphosphatidylinositol transamidase in Saccharomyces cerevisiae. Zhu Y, et al. Biochim Biophys Acta, 2005 Jun 15. PMID 15939668
  5. Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT). Yi L, et al. Sci Rep, 2017 Apr 4. PMID 28374821, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of GPI anchor to protein IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GPI-anchor transamidase GPI17
NP_010722.3
  • Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1331237..1332841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180742.3 → NP_010722.3  TPA: GPI-anchor transamidase GPI17 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010722.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT61, Q04080
    UniProtKB/TrEMBL
    B3LFM5, B5VGW5, C7GTN8, C8Z5Z5, N1P8W9
    Conserved Domains (1) summary
    pfam10510
    Location:13 → 502
    PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04080.1

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