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SXM1 Sxm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852004, updated on 4-Jan-2025

Summary

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Official Symbol
SXM1
Official Full Name
Sxm1p
Primary source
SGD:S000002803
Locus tag
YDR395W
See related
AllianceGenome:SGD:S000002803; FungiDB:YDR395W; VEuPathDB:YDR395W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KAP108
Summary
Enables nuclear import signal receptor activity. Involved in mRNA export from nucleus and protein import into nucleus. Located in cytoplasm and nucleus. Orthologous to human IPO8 (importin 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SXM1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1263324..1266158)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene She9p Neighboring gene proteasome regulatory particle base subunit RPT3 Neighboring gene negative cofactor 2 transcription regulator complex subunit NCB2 Neighboring gene Utp5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor. Freedman ND, et al. Mol Biol Cell, 2004 May. PMID 15004228, Free PMC Article
  2. Characterization of karyopherins in androgen receptor intracellular trafficking in the yeast model. Nguyen MM, et al. Int J Clin Exp Pathol, 2014. PMID 25031696, Free PMC Article
  3. Efficient nuclear transport of structurally disturbed cargo: mutations in a cargo protein switch its cognate karyopherin. Chaves SR, et al. PLoS One, 2011 Feb 9. PMID 21347375, Free PMC Article
  4. Nuclear import and the evolution of a multifunctional RNA-binding protein. Rosenblum JS, et al. J Cell Biol, 1998 Nov 16. PMID 9817748, Free PMC Article
  5. Importin/karyopherin protein family members required for mRNA export from the nucleus. Seedorf M, et al. Proc Natl Acad Sci U S A, 1997 Aug 5. PMID 9238021, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear import signal receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear import signal receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sxm1p
NP_010683.3
  • Nuclear transport factor (karyopherin); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1263324..1266158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180703.3 → NP_010683.3  TPA: Sxm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010683.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT29, Q04175
    UniProtKB/TrEMBL
    A6ZYZ6, B3LFQ5, C7GSC7, C8Z5V9, N1P7C9
    Conserved Domains (1) summary
    COG5656
    Location:3 → 940
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04175.1

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