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TRS23 TRAPP subunit TRS23 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851833, updated on 4-Jan-2025

Summary

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Official Symbol
TRS23
Official Full Name
TRAPP subunit TRS23
Primary source
SGD:S000002654
Locus tag
YDR246W
See related
AllianceGenome:SGD:S000002654; FungiDB:YDR246W; VEuPathDB:YDR246W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to guanyl-nucleotide exchange factor activity. Involved in chromosome organization and endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Used to study syndromic intellectual disability. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See TRS23 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (954288..954947)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex5p Neighboring gene alpha-1,6-mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene putative serine/threonine protein kinase VHS1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability. Van Bergen NJ, et al. Brain, 2020 Jan 1. PMID 31794024, Free PMC Article
  2. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Cai H, et al. Nature, 2007 Feb 22. PMID 17287728
  3. The SMS domain of Trs23p is responsible for the in vitro appearance of the TRAPP I complex in Saccharomyces cerevisiae. Brunet S, et al. Cell Logist, 2012 Jan 1. PMID 22645708, Free PMC Article
  4. Trs20 is required for TRAPP III complex assembly at the PAS and its function in autophagy. Taussig D, et al. Traffic, 2014 Mar. PMID 24329977, Free PMC Article
  5. The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cai Y, et al. Cell, 2008 Jun 27. PMID 18585354, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPP complex IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPPI protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPPII protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPPIII protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TRAPP subunit TRS23
NP_010532.3
  • Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homolog is TRAPPC4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    954288..954947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180554.3 → NP_010532.3  TPA: TRAPP subunit TRS23 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010532.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSM6, Q03784
    UniProtKB/TrEMBL
    A6ZYJ8, B3LG43, B5VGD2, C7GTI1, C8Z5F7, G2WAY9, N1P8H1
    Conserved Domains (1) summary
    COG5122
    Location:1 → 218
    TRS23; Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03784.1

Gene LinkOut

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