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KGD2 dihydrolipoyl transsuccinylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851726, updated on 4-Jan-2025

Summary

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Official Symbol
KGD2
Official Full Name
dihydrolipoyl transsuccinylase
Primary source
SGD:S000002555
Locus tag
YDR148C
See related
AllianceGenome:SGD:S000002555; FungiDB:YDR148C; VEuPathDB:YDR148C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dihydrolipoyllysine-residue succinyltransferase activity. Involved in 2-oxoglutarate metabolic process and cellular respiration. Located in mitochondrial nucleoid. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See KGD2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (753675..755066, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-binding transcription factor SWI5 Neighboring gene bifunctional choline kinase/ethanolamine kinase EKI1 Neighboring gene Num1p Neighboring gene putative mRNA-binding protein CTH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo assembly of yeast mitochondrial alpha-ketoglutarate dehydrogenase complex. Repetto B, et al. Mol Cell Biol, 1991 Aug. PMID 2072900, Free PMC Article
  2. Structure and regulation of KGD2, the structural gene for yeast dihydrolipoyl transsuccinylase. Repetto B, et al. Mol Cell Biol, 1990 Aug. PMID 2115121, Free PMC Article
  3. Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix. Garg S, et al. Genome Biol Evol, 2015 Sep 2. PMID 26338186, Free PMC Article
  4. Identification of the YMN-1 antigen protein and biochemical analyses of protein components in the mitochondrial nucleoid fraction of the yeast Saccharomyces cerevisiae. Sato H, et al. Protoplasma, 2002 Feb. PMID 11926067
  5. The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase. Heublein M, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165143, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dihydrolipoyllysine-residue succinyltransferase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oxoglutarate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydrolipoyl transsuccinylase
NP_010432.3
  • Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    753675..755066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180455.3 → NP_010432.3  TPA: dihydrolipoyl transsuccinylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010432.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSD1, P19262
    UniProtKB/TrEMBL
    B3LGD2, C7GIQ3, C8Z564, G2WAP8, N1P4T9
    Conserved Domains (1) summary
    TIGR01347
    Location:74 → 463
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19262.2

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