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GPR1 Gpr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851527, updated on 4-Jan-2025

Summary

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Official Symbol
GPR1
Official Full Name
Gpr1p
Primary source
SGD:S000002193
Locus tag
YDL035C
See related
AllianceGenome:SGD:S000002193; FungiDB:YDL035C; VEuPathDB:YDL035C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-glucose binding activity and G protein-coupled receptor activity. Involved in several processes, including detection of sucrose stimulus; invasive growth in response to glucose limitation; and sugar mediated signaling pathway. Located in plasma membrane. Orthologous to human GPR157 (G protein-coupled receptor 157). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GPR1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (389172..392057, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Bsc1p Neighboring gene pseudouridine synthase PUS9 Neighboring gene tRNA-5-taurinomethyluridine 2-sulfurtransferase Neighboring gene putative ATP-dependent RNA helicase DBP10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Large Scale Synthetic Site Saturation GPCR Libraries Reveal Novel Mutations That Alter Glucose Signaling. Öling D, et al. ACS Synth Biol, 2018 Sep 21. PMID 30114904
  2. Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. Lemaire K, et al. Mol Cell, 2004 Oct 22. PMID 15494315
  3. G-protein coupled receptor from yeast Saccharomyces cerevisiae. Yun CW, et al. Biochem Biophys Res Commun, 1997 Nov 17. PMID 9388468
  4. Gpr1p, a putative G-protein coupled receptor, regulates glucose-dependent cellular cAMP level in yeast Saccharomyces cerevisiae. Yun CW, et al. Biochem Biophys Res Commun, 1998 Nov 9. PMID 9813141
  5. Less is more or more is less: Implications of glucose metabolism in the regulation of the reproductive potential and total lifespan of the Saccharomyces cerevisiae yeast. Maslanka R, et al. J Cell Physiol, 2019 Aug. PMID 30805924

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Signalling pathways co-operate in the anticipatory Hxt5p activity in glucose-starved cells: surprisingly, the sugar-dependent G-protein-coupled Gpr1 is a key element.
    Title: Differential regulation of glucose transport activity in yeast by specific cAMP signatures.
  2. proteins Gpr1 and Gpa2 are involved in glucose sensing and signal transduction during pexophagy process in yeast
    Title: G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-glucose binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of sucrose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glucose mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hexose mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hexose mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in sucrose mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Gpr1p
NP_010249.1
  • Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    389172..392057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180094.1 → NP_010249.1  TPA: Gpr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010249.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRV9, Q12361
    UniProtKB/TrEMBL
    B3LGT6, N1PAA7
    Conserved Domains (3) summary
    pfam11710
    Location:52 → 279
    Git3; G protein-coupled glucose receptor regulating Gpa2
    pfam11970
    Location:610 → 685
    GPR_Gpa2_C; G protein-coupled glucose receptor regulating Gpa2 C-term
    cd14964
    Location:85 → 107
    7tm_GPCRs; TM helix 2 [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12361.1

Gene LinkOut

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