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USO1 Uso1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851501, updated on 4-Jan-2025

Summary

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Official Symbol
USO1
Official Full Name
Uso1p
Primary source
SGD:S000002216
Locus tag
YDL058W
See related
AllianceGenome:SGD:S000002216; FungiDB:YDL058W; VEuPathDB:YDL058W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
INT1
Summary
Involved in Golgi vesicle docking; SNARE complex assembly; and endoplasmic reticulum to Golgi vesicle-mediated transport. Located in ER to Golgi transport vesicle membrane and Golgi membrane. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See USO1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (345665..351037)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tsr1p Neighboring gene Rad59p Neighboring gene uncharacterized protein Neighboring gene transcription factor MBP1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cytoskeleton-related gene, uso1, is required for intracellular protein transport in Saccharomyces cerevisiae. Nakajima H, et al. J Cell Biol, 1991 Apr. PMID 2010462, Free PMC Article
  2. Antigenic and functional conservation of an integrin I-domain in Saccharomyces cerevisiae. Hostetter MK, et al. Biochem Mol Med, 1995 Aug. PMID 7582869
  3. Uso1 protein contains a coiled-coil rod region essential for protein transport from the ER to the Golgi apparatus in Saccharomyces cerevisiae. Seog DH, et al. J Biochem, 1994 Dec. PMID 7706227
  4. Specific membrane recruitment of Uso1 protein, the essential endoplasmic reticulum-to-Golgi tethering factor in yeast vesicular transport. Noda Y, et al. J Cell Biochem, 2007 Jun 1. PMID 17192843
  5. Molecular characterization of the USO1 gene product which is essential for vesicular transport in Saccharomyces cerevisiae. Seog DH, et al. Biochem Biophys Res Commun, 1994 Apr 15. PMID 8166741

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi vesicle docking IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in SNARE complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion with Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ER to Golgi transport vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Uso1p
NP_010225.1
  • Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    345665..351037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180117.1 → NP_010225.1  TPA: Uso1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010225.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRT8, E9PAG8, P25386, P89892, Q07380
    UniProtKB/TrEMBL
    B3LGV6
    Conserved Domains (3) summary
    COG1196
    Location:898 → 1733
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam04869
    Location:366 → 715
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    NF033777
    Location:783 → 915
    M_group_A_cterm; M protein C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25386.2

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