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SCM3 Scm3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851416, updated on 4-Jan-2025

Summary

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Official Symbol
SCM3
Official Full Name
Scm3p
Primary source
SGD:S000002298
Locus tag
YDL139C
See related
AllianceGenome:SGD:S000002298; FungiDB:YDL139C; VEuPathDB:YDL139C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables CENP-A containing nucleosome binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; kinetochore assembly; and negative regulation of ubiquitin-dependent protein catabolic process. Located in condensed chromosome, centromeric region. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SCM3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (211375..212046, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene biotin--[acetyl-CoA-carboxylase] ligase BPL1 Neighboring gene DNA-directed RNA polymerase II core subunit RPO21 Neighboring gene glucose sensor Neighboring gene Arf family GTPase ARF2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Domain architectures of the Scm3p protein provide insights into centromere function and evolution. Aravind L, et al. Cell Cycle, 2007 Oct 15. PMID 17704645, Free PMC Article
  2. Common ancestry of the CENP-A chaperones Scm3 and HJURP. Sanchez-Pulido L, et al. Cell, 2009 Jun 26. PMID 19563746, Free PMC Article
  3. Backbone and side-chain resonance assignments of centromeric protein Scm3 from Saccharomyces cerevisiae. Bhattacharya A, et al. Biomol NMR Assign, 2019 Oct. PMID 30937734
  4. Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization. Stoler S, et al. Proc Natl Acad Sci U S A, 2007 Jun 19. PMID 17548816, Free PMC Article
  5. Cse4 (CenH3) association with the Saccharomyces cerevisiae plasmid partitioning locus in its native and chromosomally integrated states: implications in centromere evolution. Huang CC, et al. Mol Cell Biol, 2011 Mar. PMID 21173161, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cse4 and H3 are structurally compatible to be incorporated in the same nucleosome to form heterotypic particles during Scm3-mediated nucleosome assembly.
    Title: Scm3 deposits a (Cse4-H4)2 tetramer onto DNA through a Cse4-H4 dimer intermediate.
  2. Scm3 becomes 2.5-fold enriched at kinetochores in anaphase after incorporation of Ces4 and then dissociated from kinetochores with mitotic exit.
    Title: The CENP-A chaperone Scm3 becomes enriched at kinetochores in anaphase independently of CENP-A incorporation.
  3. stringent regulation of HJURP and SCM3 expression are critical for genome stability.
    Title: Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.
  4. Scm3 functions as a Cse4-specific nucleosome assembly factor, and the resulting octameric nucleosomes do not contain Scm3 as a stably bound component.
    Title: Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomes.
  5. Study propose that Scm3 plays an active role in centromeric nucleosome assembly.
    Title: Scm3 is a centromeric nucleosome assembly factor.
  6. Ndc10/Scm3 binds to centromeric DNA, which is in turn essential for targeting Cse4 to centromeres.
    Title: Scm3 is essential to recruit the histone h3 variant cse4 to centromeres and to maintain a functional kinetochore.
  7. nonhistone Scm3 serves to assemble and maintain Cse4-H4 at centromeres and may replace histone H2A-H2B dimers in a centromere-specific nucleosome core
    Title: Nonhistone Scm3 and histones CenH3-H4 assemble the core of centromere-specific nucleosomes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables CENP-A containing nucleosome binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables CENP-A containing nucleosome binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to chromosome, centromeric region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome, centromeric region IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Scm3p
NP_010142.2
  • Non-histone component of centromeric chromatin; acts as a Cse4p specific chaperone that recognizes the centromere-targeting domain in the HFD of histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitination; homolog of mammalian HJURP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    211375..212046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180199.1 → NP_010142.2  TPA: Scm3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010142.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRK9, Q12334
    UniProtKB/TrEMBL
    C7GKZ1, G2WC22, N1P7V3
    Conserved Domains (1) summary
    pfam10384
    Location:92 → 141
    Scm3; Centromere protein Scm3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12334.2

Gene LinkOut

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