U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NHP2 snoRNA-binding protein NHP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851319, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
NHP2
Official Full Name
snoRNA-binding protein NHP2
Primary source
SGD:S000002367
Locus tag
YDL208W
See related
AllianceGenome:SGD:S000002367; FungiDB:YDL208W; VEuPathDB:YDL208W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables box H/ACA snoRNA binding activity. Involved in box H/ACA snoRNP assembly; rRNA pseudouridine synthesis; and snRNA pseudouridine synthesis. Part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NHP2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (87512..87982)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Uga4p Neighboring gene Cwc2p Neighboring gene nucleoporin GLE1 Neighboring gene Ycx1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sequence and genetic analysis of NHP2: a moderately abundant high mobility group-like nuclear protein with an essential function in Saccharomyces cerevisiae. Kolodrubetz D, et al. Yeast, 1991 Feb. PMID 2063628
  2. Functional conservation and cell cycle localization of the Nhp2 core component of H + ACA snoRNPs in fission and budding yeasts. Maiorano D, et al. Exp Cell Res, 1999 Oct 10. PMID 10502409
  3. Accumulation of H/ACA snoRNPs depends on the integrity of the conserved central domain of the RNA-binding protein Nhp2p. Henras A, et al. Nucleic Acids Res, 2001 Jul 1. PMID 11433018, Free PMC Article
  4. Increasing the Depth of Mass-Spectrometry-Based Structural Analysis of Protein Complexes through the Use of Multiple Cross-Linkers. Ding YH, et al. Anal Chem, 2016 Apr 19. PMID 27010980
  5. The cotranscriptional assembly of snoRNPs controls the biosynthesis of H/ACA snoRNAs in Saccharomyces cerevisiae. Ballarino M, et al. Mol Cell Biol, 2005 Jul. PMID 15964797, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables box H/ACA snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables box H/ACA snoRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in box H/ACA snoRNP assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of box H/ACA snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box H/ACA snoRNP complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
snoRNA-binding protein NHP2
NP_010073.2
  • Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    87512..87982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180268.1 → NP_010073.2  TPA: snoRNA-binding protein NHP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010073.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRE6, P32495
    UniProtKB/TrEMBL
    A6ZXC5, B3LH88, C7GV69, C8Z6R1, G2WBV9, N1P6N3
    Conserved Domains (1) summary
    COG1358
    Location:30 → 143
    Rpl7Ae; Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32495.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools