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CDC15 serine/threonine protein kinase CDC15 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851274, updated on 4-Jan-2025

Summary

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Official Symbol
CDC15
Official Full Name
serine/threonine protein kinase CDC15
Primary source
SGD:S000000072
Locus tag
YAR019C
See related
AllianceGenome:SGD:S000000072; FungiDB:YAR019C; VEuPathDB:YAR019C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LYT1; RLT1
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including meiotic spindle disassembly; negative regulation of protein localization to nucleolus; and regulation of cell cycle process. Located in cellular bud neck and spindle pole body. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CDC15 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (172211..175135, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene serine/threonine protein kinase KIN3 Neighboring gene seripauperin PAU7 Neighboring gene DUP240 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain. Schweitzer B, et al. Yeast, 1991 Apr. PMID 1882551
  2. Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions. Lopez V, et al. Genes Dev, 2015 Feb 1. PMID 25644606, Free PMC Article
  3. A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae. Asakawa K, et al. Genetics, 2001 Apr. PMID 11290702, Free PMC Article
  4. Costs, benefits and redundant mechanisms of adaption to chronic low-dose stress in yeast. Markiewicz-Potoczny M, et al. Cell Cycle, 2016 Oct 17. PMID 27628486, Free PMC Article
  5. A cdc-like autolytic Saccharomyces cerevisiae mutant altered in budding site selection is complemented by SPO12, a sporulation gene. Molero G, et al. J Bacteriol, 1993 Oct. PMID 8407833, Free PMC Article

See all (170) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.
    Title: A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.
  2. Cdc15 also influences the complete transcription of clb2 gene and phosphorylates Ser-5 at the promoter and Ser-2 toward the 3' end of the gene
    Title: Cdc15 Phosphorylates the C-terminal Domain of RNA Polymerase II for Transcription during Mitosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to nucleolus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ascospore-type prospore membrane formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of ascospore-type prospore membrane formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine protein kinase CDC15
NP_009411.2
  • Hippo-like kinase of the Mitotic Exit Network; promotes exit by activating the Dbf2p kinase; component of a non-canonical Hippo pathway with Sps1p required for prospore membrane closure, spindle disassembly and sustained release of Cdc14p during meiotic anaphase II; complexes with Sps1p and contributes to its phosphorylation; phosphorylates the RNAPII CTD during mitosis; localizes to the bud neck and SPB during anaphase and telophase; relocalizes to the cytoplasm upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    172211..175135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178218.2 → NP_009411.2  TPA: serine/threonine protein kinase CDC15 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009411.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPM6, P27636
    UniProtKB/TrEMBL
    A7A0H5, C7GUF8, N1P940
    Conserved Domains (1) summary
    cl21453
    Location:24 → 272
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27636.3

Gene LinkOut

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