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MAG2 Mag2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851147, updated on 4-Jan-2025

Summary

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Official Symbol
MAG2
Official Full Name
Mag2p
Primary source
SGD:S000004419
Locus tag
YLR427W
See related
AllianceGenome:SGD:S000004419; FungiDB:YLR427W; VEuPathDB:YLR427W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin protein ligase activity. Involved in nonfunctional rRNA decay and protein monoubiquitination. Located in cytoplasm. Is active in cytosolic ribosome. Orthologous to human RNF10 (ring finger protein 10). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MAG2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (988428..990440)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rho family guanine nucleotide exchange factor TUS1 Neighboring gene Tda5p Neighboring gene Crn1p Neighboring gene DNA/RNA helicase SEN1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic approach for validating the ubiquitinated proteome. Seyfried NT, et al. Anal Chem, 2008 Jun 1. PMID 18433149, Free PMC Article
  2. Sequential Ubiquitination of Ribosomal Protein uS3 Triggers the Degradation of Non-functional 18S rRNA. Sugiyama T, et al. Cell Rep, 2019 Mar 19. PMID 30893611
  3. Mechanisms of patulin toxicity under conditions that inhibit yeast growth. Iwahashi Y, et al. J Agric Food Chem, 2006 Mar 8. PMID 16506856
  4. Predicting protein functions from redundancies in large-scale protein interaction networks. Samanta MP, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14566057, Free PMC Article
  5. A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. Choi J, et al. PLoS One, 2017. PMID 28520786, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in nonfunctional rRNA decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mag2p
NP_013531.3
  • Cytoplasmic RING-finger type E3 ubiquitin ligase; involved in monoubiquitination of Rps3p, a 40S subunit from decoding-defective ribosomes, leading to Fap1p-mediated K63-linked polyubiquitination, followed by dissociation of non-functional 80S ribosomes and non-functional rRNA decay (NRD) of 18S rRNA; ubiquitinated; induced in response to mycotoxin patulin; predicted to be involved in repair of alkylated DNA due to interaction with MAG1; similar to the human ring finger motif protein RNF10

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    988428..990440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182315.3 → NP_013531.3  TPA: Mag2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013531.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ63, Q06436
    UniProtKB/TrEMBL
    A7A1U8, C8ZE35, N1NZW7
    Conserved Domains (1) summary
    cd16536
    Location:195 → 249
    RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06436.1

Gene LinkOut

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