U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GRX8 glutathione-disulfide reductase GRX8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851079, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
GRX8
Official Full Name
glutathione-disulfide reductase GRX8
Primary source
SGD:S000004356
Locus tag
YLR364W
See related
AllianceGenome:SGD:S000004356; FungiDB:YLR364W; VEuPathDB:YLR364W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutathione-disulfide reductase (NADPH) activity. Predicted to be involved in cellular oxidant detoxification. Located in cytoplasm. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GRX8 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (854062..854391)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Nmd4p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S22B Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure-guided activity enhancement and catalytic mechanism of yeast grx8. Tang Y, et al. Biochemistry, 2014 Apr 8. PMID 24611845
  2. Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insight into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins. Mesecke N, et al. Biochemistry, 2008 Feb 5. PMID 18171082
  3. Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux. Eckers E, et al. Biochemistry, 2009 Feb 17. PMID 19166312
  4. Integrating phenotypic and expression profiles to map arsenic-response networks. Haugen AC, et al. Genome Biol, 2004. PMID 15575969, Free PMC Article
  5. αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import. Ponce-Rojas JC, et al. FEBS J, 2017 Mar. PMID 28109174

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. catalytic mechanism of yeast grx8
    Title: Structure-guided activity enhancement and catalytic mechanism of yeast grx8.
  2. ScGrx8 has several novel structural and mechanistic features expanding the subclasses of glutaredoxins.
    Title: Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glutathione-disulfide reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glutathione-disulfide reductase GRX8
NP_013468.3
  • Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    854062..854391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182253.3 → NP_013468.3  TPA: glutathione-disulfide reductase GRX8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013468.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ03, Q05926
    UniProtKB/TrEMBL
    A7A1P3, B3RHN3, C7GRW0, C8ZDX3, G2WJI3, N1P791
    Conserved Domains (1) summary
    COG0695
    Location:21 → 99
    GrxC; Glutaredoxin [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05926.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools