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ACF2 endo-1,3(4)-beta-glucanase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850836, updated on 4-Jan-2025

Summary

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Official Symbol
ACF2
Official Full Name
endo-1,3(4)-beta-glucanase
Primary source
SGD:S000004134
Locus tag
YLR144C
See related
AllianceGenome:SGD:S000004134; FungiDB:YLR144C; VEuPathDB:YLR144C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ENG2; PCA1
Summary
Enables glucan endo-1,3-beta-D-glucosidase activity. Involved in actin cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ACF2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (429677..432016, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene diphthine--ammonia ligase Neighboring gene Rmp1p Neighboring gene spermine synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of PCEng2, a {beta}-1,3-endoglucanase homolog in Pneumocystis carinii with activity in cell wall regulation. Villegas LR, et al. Am J Respir Cell Mol Biol, 2010 Aug. PMID 19783787, Free PMC Article
  2. Eng1p, an endo-1,3-beta-glucanase localized at the daughter side of the septum, is involved in cell separation in Saccharomyces cerevisiae. Baladrón V, et al. Eukaryot Cell, 2002 Oct. PMID 12455695, Free PMC Article
  3. Characterization of the endo-beta-1,3-glucanase activity of S. cerevisiae Eng2 and other members of the GH81 family. Martín-Cuadrado AB, et al. Fungal Genet Biol, 2008 Apr. PMID 17933563
  4. In vitro reconstitution of cortical actin assembly sites in budding yeast. Lechler T, et al. J Cell Biol, 1997 Jul 14. PMID 9214384, Free PMC Article
  5. Saccharomyces spores are born prepolarized to outgrow away from spore-spore connections and penetrate the ascus wall. Heasley LR, et al. Yeast, 2021 Jan. PMID 33238051, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. four conserved Asp and Glu residues (D518, D588, E609, and E613) are necessary for enzymatic activity.
    Title: Characterization of the endo-beta-1,3-glucanase activity of S. cerevisiae Eng2 and other members of the GH81 family.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables endo-1,3(4)-beta-glucanase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucan endo-1,3-beta-D-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucan endo-1,3-beta-D-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucan endo-1,3-beta-D-glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucan endo-1,3-beta-D-glucosidase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in polysaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endo-1,3(4)-beta-glucanase
NP_013245.1
  • Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    429677..432016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182031.1 → NP_013245.1  TPA: endo-1,3(4)-beta-glucanase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013245.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYD8, Q07268, Q12168
    UniProtKB/TrEMBL
    A7A142, B3LTA4, B5VN75, C7GMJ5, C8ZDB3, N1NYA4
    Conserved Domains (1) summary
    COG5498
    Location:1 → 779
    Acf2; Endoglucanase Acf2 [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12168.1

Gene LinkOut

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