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MIC19 Mic19p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850563, updated on 4-Jan-2025

Summary

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Official Symbol
MIC19
Official Full Name
Mic19p
Primary source
SGD:S000001907
Locus tag
YFR011C
See related
AllianceGenome:SGD:S000001907; FungiDB:YFR011C; VEuPathDB:YFR011C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AIM13; MCS19
Summary
Involved in cristae formation. Located in mitochondrial crista junction. Part of MICOS complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MIC19 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (166746..167258, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene putative AAA family ATPase GCN20 Neighboring gene ubiquitin-specific protease UBP6 Neighboring gene tRNA-Tyr Neighboring gene Dcv1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Oxidation Status of Mic19 Regulates MICOS Assembly. Sakowska P, et al. Mol Cell Biol, 2015 Dec. PMID 26416881, Free PMC Article
  2. Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System. Zerbes RM, et al. J Mol Biol, 2016 Apr 24. PMID 26968360
  3. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Harner ME, et al. Elife, 2014 Jan 1. PMID 24714493, Free PMC Article
  4. Myristoyl group-aided protein import into the mitochondrial intermembrane space. Ueda E, et al. Sci Rep, 2019 Feb 4. PMID 30718713, Free PMC Article
  5. The mitochondrial contact site complex, a determinant of mitochondrial architecture. Harner M, et al. EMBO J, 2011 Oct 18. PMID 22009199, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MICOS complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in mitochondrial crista junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mic19p
NP_116666.1
  • Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane and may connect Mic60p with the Mic10p-Mic12p-Mic27p subcomplex; both yeast and human Mic19p become oxidized, and oxidation may regulate MICOS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    166746..167258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179976.1 → NP_116666.1  TPA: Mic19p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116666.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTP1, P43594
    UniProtKB/TrEMBL
    A7A249, B3LUL9, B5VI37, C7GYB7, C8Z7U6, G2WDF0, N1PA27
    Conserved Domains (1) summary
    pfam07956
    Location:18 → 168
    DUF1690; Protein of Unknown function (DUF1690)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43594.1

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