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SOL2 Sol2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850437, updated on 4-Jan-2025

Summary

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Official Symbol
SOL2
Official Full Name
Sol2p
Primary source
SGD:S000000718
Locus tag
YCR073W-A
See related
AllianceGenome:SGD:S000000718; FungiDB:YCR073W-A; VEuPathDB:YCR073W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YCRX13W
Summary
Predicted to enable 6-phosphogluconolactonase activity. Involved in tRNA export from nucleus. Located in cytosol. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SOL2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (246963..247910)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Rsa4p Neighboring gene mitogen-activated protein kinase kinase kinase SSK22 Neighboring gene cystinosin-like protein ERS1 Neighboring gene Ego2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family. Shen WC, et al. Genetics, 1996 Jun. PMID 8725220, Free PMC Article
  2. Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism. Stanford DR, et al. Genetics, 2004 Sep. PMID 15454531, Free PMC Article
  3. The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Musso G, et al. Genome Res, 2008 Jul. PMID 18463300, Free PMC Article
  4. Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Pinsky BA, et al. Mol Cell Biol, 2006 Apr. PMID 16537909, Free PMC Article
  5. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Mok J, et al. Sci Signal, 2010 Feb 16. PMID 20159853, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 6-phosphogluconolactonase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sol2p
NP_009999.2
  • Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    246963..247910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178815.1 → NP_009999.2  TPA: Sol2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009999.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR76, P37262
    UniProtKB/TrEMBL
    A6ZTP7, C7GUX3, G2WA83
    Conserved Domains (1) summary
    cd01400
    Location:87 → 292
    6PGL; 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37262.2

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