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SED4 GTPase-activating protein SED4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850431, updated on 4-Jan-2025

Summary

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Official Symbol
SED4
Official Full Name
GTPase-activating protein SED4
Primary source
SGD:S000000663
Locus tag
YCR067C
See related
AllianceGenome:SGD:S000000663; FungiDB:YCR067C; VEuPathDB:YCR067C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in regulation of COPII vesicle coating. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SED4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (233125..236322, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Hcm1p Neighboring gene E3 ubiquitin-protein ligase RAD18 Neighboring gene triglyceride lipase ATG15 Neighboring gene peptidylprolyl isomerase family protein CPR4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sec16 and Sed4 interdependently function as interaction and localization partners at ER exit sites. Yorimitsu T, et al. J Cell Sci, 2023 May 1. PMID 37158682, Free PMC Article
  2. Sed4p stimulates Sar1p GTP hydrolysis and promotes limited coat disassembly. Kodera C, et al. Traffic, 2011 May. PMID 21291503
  3. Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat. Kung LF, et al. EMBO J, 2012 Feb 15. PMID 22157747, Free PMC Article
  4. Combinatorial multivalent interactions drive cooperative assembly of the COPII coat. Stancheva VG, et al. J Cell Biol, 2020 Nov 2. PMID 32997735, Free PMC Article
  5. Genes that allow yeast cells to grow in the absence of the HDEL receptor. Hardwick KG, et al. EMBO J, 1992 Nov. PMID 1327759, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of COPII vesicle coating IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTPase-activating protein SED4
NP_009993.1
  • Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    233125..236322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178778.1 → NP_009993.1  TPA: GTPase-activating protein SED4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR70, P25365
    UniProtKB/TrEMBL
    B3LUC5, C7GUX8
    Conserved Domains (3) summary
    sd00039
    Location:172 → 209
    7WD40; WD40 repeat [structural motif]
    NF033849
    Location:727 → 1009
    ser_rich_anae_1; serine-rich protein
    cl29593
    Location:171 → 330
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25365.1

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