NPP1 nucleotide diphosphatase/phosphodiesterase NPP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NPP1
Official Full Name: nucleotide diphosphatase/phosphodiesterase NPP1
Primary source: SGD:S000000621
Locus tag: YCR026C
See related: AllianceGenome:SGD:S000000621; FungiDB:YCR026C; VEuPathDB:YCR026C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables nucleoside triphosphate diphosphatase activity and ribonucleoside triphosphate phosphatase activity. Involved in cellular response to phosphate starvation and nucleoside triphosphate metabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to several human genes including ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4) and ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See NPP1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (164111..166339, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that two orthologs of the E-NPP family, referred to as Npp1p and Npp2p, exist in budding yeast, can perform nucleotide phosphate hydrolysis, and can act in concert with Pho5p.
Title: Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 8-oxo-(d)RTP hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside triphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside triphosphate diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables nucleoside triphosphate diphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphodiesterase I activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ribonucleoside triphosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to phosphate starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside triphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside triphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organophosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleotide diphosphatase/phosphodiesterase NPP1

NP_009955.2

EC 3.1.4.1

EC 3.6.1.9

Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

164111..166339 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178741.1 → NP_009955.2 TPA: nucleotide diphosphatase/phosphodiesterase NPP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009955.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR36, P25353, Q8NIL9

UniProtKB/TrEMBL

G2WA44, N1P7V5

Conserved Domains (1) summary

pfam01663
Location:170 → 545

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase