MT4 metallothionein 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MT4provided by HGNC
Official Full Name: metallothionein 4provided by HGNC
Primary source: HGNC:HGNC:18705
See related: Ensembl:ENSG00000102891 MIM:606206; AllianceGenome:HGNC:18705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MT-4; MTIV; MT-IV
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including cellular response to zinc ion; detoxification of copper ion; and intracellular zinc ion homeostasis. Predicted to act upstream of or within intracellular monoatomic cation homeostasis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 16q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (56565073..56568957)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (62359992..62363895)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (56598985..56602869)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MT4 expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.
The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers
Title: The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers.
Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers.
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
Title: Genetic background of lead and mercury metabolism in a group of medical students in Austria.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Interaction Database

General gene information

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Markers

NoName (e-PCR)
- UniSTS:485843

STS-U07807 (e-PCR)
- UniSTS:32215

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: metallothionein-4

Names: metallothionein-IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032935.3 → NP_116324.2 metallothionein-4

Status: VALIDATED

Source sequence(s)

AC026461

Consensus CDS

CCDS42165.1

UniProtKB/Swiss-Prot

P47944, Q14DA1

Related

ENSP00000219162.3, ENST00000219162.4

Conserved Domains (1) summary

pfam00131
Location:5 → 61

Metallothio; Metallothionein