ERH3 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ERH3
Official Full Name: P-loop containing nucleoside triphosphate hydrolases superfamily protein
Primary source: TAIR:AT1G80350
Locus tag: AT1G80350
See related: Araport:AT1G80350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AAA1; ARABIDOPSIS THALIANA KATANIN SMALL SUBUNIT; ATKSS; ATKTN1; BOT1; BOTERO 1; CAD ATPASE; ECTOPIC ROOT HAIR 3; F5I6.10; F5I6_10; FAT ROOT; FRA2; FRAGILE FIBER 2; FRC2; FTR; FURCA2; KATANIN 1; KTN1; LUE1
Summary: encodes a p60 katanin protein that is expressed throughout the plant. Required for the specification of cell fates from early in development (in the meristem) through differentiation and for normal postmitotic organization of cortical microtubules into transverse arrays in root epidermis cells. Mutants display cytoskeletal defects.
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Genomic context

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See ERH3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 7

Sequence:: Chromosome: 1; NC_003070.9 (30205314..30208268, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brassinosteroid signals cooperate with katanin-mediated microtubule severing to control stamen filament elongation.
Title: Brassinosteroid signals cooperate with katanin-mediated microtubule severing to control stamen filament elongation.
Cytokinesis in fra2 Arabidopsis thaliana p60-Katanin Mutant: Defects in Cell Plate/Daughter Wall Formation.
Title: Cytokinesis in fra2 Arabidopsis thaliana p60-Katanin Mutant: Defects in Cell Plate/Daughter Wall Formation.
KATANIN-dependent mechanical properties of the stigmatic cell wall mediate the pollen tube path in Arabidopsis.
Title: KATANIN-dependent mechanical properties of the stigmatic cell wall mediate the pollen tube path in Arabidopsis.
A Novel Katanin-Tethering Machinery Accelerates Cytokinesis.
Title: A Novel Katanin-Tethering Machinery Accelerates Cytokinesis.
Data show that FRAGILE FIBER 2 (fra2, Katanin mutant had an increased infection rate.
Title: Cell Wall Modifications in Giant Cells Induced by the Plant Parasitic Nematode Meloidogyne incognita in Wild-Type (Col-0) and the fra2 Arabidopsis thaliana Katanin Mutant.
Work reveals that cross-linking of microtubules by MAP65-1 confers resistance to severing by inhibiting the binding of KTN1 and identifies the structural features of MAP65-1 that are important for this activity.
Title: Microtubule bundling by MAP65-1 protects against severing by inhibiting the binding of katanin.
The conserved protein CLASP is a potent stabilizer of new plus ends created by katanin severing in plant cells.
Title: CLASP stabilization of plus ends created by severing promotes microtubule creation and reorientation.
the proteome-wide effects in two KATANIN 1 mutants, are reported.
Title: Feedback Microtubule Control and Microtubule-Actin Cross-talk in Arabidopsis Revealed by Integrative Proteomic and Cell Biology Analysis of KATANIN 1 Mutants.
loss of KTN1 prevented random microtubule networks from shifting into well-ordered arrays. We further showed that the filamentous actin cap, which is a typical feature of several plant epidermal cell types including root hairs and leaf trichomes, was not observed in the growth apexes of conical cells during cell development.
Title: Spatio-temporal orientation of microtubules controls conical cell shape in Arabidopsis thaliana petals.
Severing at cortical microtubule crossover sites was completely abolished in the Arabidopsis katanin mutant. Consistent with this finding, GFP-tagged katanin driven by its native promoter localizes at sites of CMT crossover prior to severing.
Title: Microtubule severing at crossover sites by katanin generates ordered cortical microtubule arrays in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_106684.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables microtubule severing ATPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anisotropic cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect leaf pavement cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule severing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of katanin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P-loop containing nucleoside triphosphate hydrolases superfamily protein

NP_178151.1

ECTOPIC ROOT HAIR 3 (ERH3); FUNCTIONS IN: nucleoside-triphosphatase activity, nucleotide binding, ATP binding; INVOLVED IN: trichome branching, cortical microtubule organization, multidimensional cell growth, plant-type cell wall biogenesis, microtubule cytoskeleton organization; LOCATED IN: katanin complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, conserved site (InterPro:IPR003960), Vps4 oligomerisation, C-terminal (InterPro:IPR015415); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT2G34560.1); Has 31677 Blast hits to 29370 proteins in 3124 species: Archae - 1478; Bacteria - 12054; Metazoa - 4742; Fungi - 3292; Plants - 2928; Viruses - 23; Other Eukaryotes - 7160 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

30205314..30208268 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_106684.5 → NP_178151.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_178151.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8S9E4, Q9SEX2

UniProtKB/TrEMBL

A0A178WF59, A0A384L792, Q0WR11

Conserved Domains (3) summary

pfam09336
Location:479 → 521

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:434 → 478

AAA_lid_3; AAA+ lid domain

cl38936
Location:240 → 410

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases