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NADP-ME4 NADP-malic enzyme 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844314, updated on 18-Sep-2024

Summary

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Official Symbol
NADP-ME4
Official Full Name
NADP-malic enzyme 4
Primary source
TAIR:AT1G79750
Locus tag
AT1G79750
See related
Araport:AT1G79750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana NADP-malic enzyme 4; ATNADP-ME4; F19K16.27; F19K16_27; NADP-malic enzyme 4
Summary
The malic enzyme (EC 1.1.1.40) encoded by AtNADP-ME4 is localized to chloroplasts. The gene is expressed throughout the whole plant and during embryogenesis and germination. A possible involvement in the fatty acid biosynthesis has been proposed.
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Genomic context

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See NADP-ME4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
18
Sequence:
Chromosome: 1; NC_003070.9 (30007288..30011690, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene ncRNA Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene hAT transposon superfamily Neighboring gene downstream target of AGL15-4 Neighboring gene CASP-like protein (DUF1677)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A comprehensive analysis of the NADP-malic enzyme gene family of Arabidopsis. Wheeler MC, et al. Plant Physiol, 2005 Sep. PMID 16113210, Free PMC Article
  2. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
  3. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
  4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
  5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_106624.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables cobalt ion binding HDA PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within malate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within malate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
NADP-malic enzyme 4
NP_178093.1
  • NADP-malic enzyme 4 (NADP-ME4); CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NADP-malic enzyme 3 (TAIR:AT5G25880.1); Has 9573 Blast hits to 9553 proteins in 2441 species: Archae - 143; Bacteria - 6332; Metazoa - 610; Fungi - 220; Plants - 473; Viruses - 0; Other Eukaryotes - 1795 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    30007288..30011690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106624.5 → NP_178093.1  NADP-malic enzyme 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56WI7, Q9CA83, Q9MA03
    UniProtKB/TrEMBL
    A0A178W4H6
    Conserved Domains (1) summary
    PLN03129
    Location:67 → 646
    PLN03129; NADP-dependent malic enzyme; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CA83.1

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