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ALDH5F1 aldehyde dehydrogenase 5F1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 844282, updated on 18-Sep-2024

Summary

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Official Symbol
ALDH5F1
Official Full Name
aldehyde dehydrogenase 5F1
Primary source
TAIR:AT1G79440
Locus tag
AT1G79440
See related
Araport:AT1G79440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
aldehyde dehydrogenase 5F1; ENF1; ENLARGED FIL EXPRESSION DOMAIN 1; SSADH; SSADH1; SUCCINIC SEMIALDEHYDE DEHYDROGENASE; SUCCINIC SEMIALDEHYDE DEHYDROGENASE 1
Summary
Encodes a mitochondrial succinic semialdehyde dehydrogenase (SSADH). Nomenclature according to Kirch, et al (2004).
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Genomic context

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See ALDH5F1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
20
Sequence:
Chromosome: 1; NC_003070.9 (29882121..29887414, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene C-type mannose receptor (DUF620) Neighboring gene Homeodomain-like superfamily protein Neighboring gene ALA-interacting subunit 5 Neighboring gene Terpenoid cyclases/Protein prenyltransferases superfamily protein Neighboring gene Aldolase-type TIM barrel family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Busch KB, et al. Plant Physiol, 1999 Oct. PMID 10517851, Free PMC Article
  2. Plant succinic semialdehyde dehydrogenase: dissection of nucleotide binding by surface plasmon resonance and fluorescence spectroscopy. Busch K, et al. Biochemistry, 2000 Aug 22. PMID 10955999
  3. Transcript and metabolite profiling during cold acclimation of Arabidopsis reveals an intricate relationship of cold-regulated gene expression with modifications in metabolite content. Kaplan F, et al. Plant J, 2007 Jun. PMID 17461790
  4. GABA shunt deficiencies and accumulation of reactive oxygen intermediates: insight from Arabidopsis mutants. Fait A, et al. FEBS Lett, 2005 Jan 17. PMID 15642352
  5. Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Bouché N, et al. Proc Natl Acad Sci U S A, 2003 May 27. PMID 12740438, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ENF1 gene encodes SUCCINIC SEMIALDEHYDE DEHYDROGENASE (SSADH), which catalyzes the conversion of succinic semialdehyde (SSA) to succinate.
    Title: Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis.
  2. Data suggest that POP2 mutants suppress the phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis.
    Title: Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_106592.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding HDA PubMed 
enables succinate-semialdehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinate-semialdehyde dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaxial/abaxial axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cotyledon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gamma-aminobutyrate shunt IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gamma-aminobutyrate shunt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in leaf development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of shoot apical meristem identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salt IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in cytosol HDA PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase 5F1
NP_178062.1
  • aldehyde dehydrogenase 5F1 (ALDH5F1); FUNCTIONS IN: 3-chloroallyl aldehyde dehydrogenase activity, NAD or NADH binding, copper ion binding, succinate-semialdehyde dehydrogenase activity; INVOLVED IN: in 6 processes; LOCATED IN: mitochondrion, chloroplast, mitochondrial matrix; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160), Succinic semialdehyde dehydrogenase (InterPro:IPR010102); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 2B4 (TAIR:AT3G48000.1); Has 62487 Blast hits to 62143 proteins in 3037 species: Archae - 481; Bacteria - 36218; Metazoa - 2614; Fungi - 2131; Plants - 1502; Viruses - 0; Other Eukaryotes - 19541 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    29882121..29887414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106592.5 → NP_178062.1  aldehyde dehydrogenase 5F1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178062.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SAK4, Q9SEK4
    UniProtKB/TrEMBL
    A0A178W894, A0A654EVI1
    Conserved Domains (1) summary
    PLN02278
    Location:29 → 526
    PLN02278; succinic semialdehyde dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SAK4.2

Gene LinkOut

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