PIP5K2 phosphatidylinositol-4-phosphate 5-kinase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PIP5K2
Official Full Name: phosphatidylinositol-4-phosphate 5-kinase 2
Primary source: TAIR:AT1G77740
Locus tag: AT1G77740
See related: Araport:AT1G77740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: phosphatidylinositol-4-phosphate 5-kinase 2
Summary: Encodes PIP5K2, a phosphatidylinositol-4-phosphate 5-kinase (PtdIns(4)P 5-kinase 2; or PIP5K2 that is involved in regulating lateral root formation and root gravity response.
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Genomic context

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See PIP5K2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (29220349..29224426)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

contains a functional nuclear localization sequence and interacts with alpha-importins
Title: Arabidopsis phosphatidylinositol 4-phosphate 5-kinase 2 contains a functional nuclear localization sequence and interacts with alpha-importins.
PIP5K1 and PIP5K2 are expressed during early stages of pollen development and their transcriptional activity respond to auxin in pollen grains. PIP5K1, PIP5K2 and phosphoinositide signaling are important cues for early developmental stages and vacuole formation during microgametogenesis.
Title: Phosphatidylinositol 4-phosphate 5-kinases 1 and 2 are involved in the regulation of vacuole morphology during Arabidopsis thaliana pollen development.
PIP5K2 is involved in regulating lateral root formation and root gravity response, and reveal a critical role of PIP5K2/PtdIns(4,5)P(2) in root development through regulation of PIN proteins, providing direct evidence of crosstalk between the phosphatidylinositol signaling pathway and auxin response, and new insights into the control of polar auxin transport
Title: Arabidopsis phosphatidylinositol monophosphate 5-kinase 2 is involved in root gravitropism through regulation of polar auxin transport by affecting the cycling of PIN proteins.
Data propose that plant cells exhibit a novel interaction in which PIP5K2 binds GTP-bound Rab-E proteins, which may stimulate temporally or spatially localized PtdIns(4,5)P(2) production at the plasma membrane.
Title: Arabidopsis Rab-E GTPases exhibit a novel interaction with a plasma-membrane phosphatidylinositol-4-phosphate 5-kinase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001334792.1

Supported by ESTs:

NM_106423.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental process involved in reproduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol-4-phosphate 5-kinase 2

NP_001319397.1

phosphatidylinositol-4-phosphate 5-kinase 2 (PIP5K2); CONTAINS InterPro DOMAIN/s: Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup (InterPro:IPR016034), Phosphatidylinositol-4-phosphate 5-kinase, plant (InterPro:IPR017163), MORN motif (InterPro:IPR003409), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: phosphatidylinositol-4-phosphate 5-kinase 1 (TAIR:AT1G21980.1); Has 28568 Blast hits to 7904 proteins in 613 species: Archae - 0; Bacteria - 4095; Metazoa - 4135; Fungi - 445; Plants - 2701; Viruses - 0; Other Eukaryotes - 17192 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

29220349..29224426

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001334792.1 → NP_001319397.1 phosphatidylinositol-4-phosphate 5-kinase 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L796, Q9CA20

UniProtKB/TrEMBL

A0A178W978, A0A5S9WV91

Conserved Domains (1) summary

PLN03185
Location:73 → 750

PLN03185; phosphatidylinositol phosphate kinase; Provisional
NM_106423.2 → NP_177897.1 phosphatidylinositol-4-phosphate 5-kinase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177897.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L796, Q9CA20

UniProtKB/TrEMBL

A0A178W978, A0A5S9WV91

Conserved Domains (1) summary

PLN03185
Location:73 → 750

PLN03185; phosphatidylinositol phosphate kinase; Provisional