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HB33 homeobox protein 33 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843861, updated on 18-Sep-2024

Summary

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Official Symbol
HB33
Official Full Name
homeobox protein 33
Primary source
TAIR:AT1G75240
Locus tag
AT1G75240
See related
Araport:AT1G75240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtHB33; F22H5.4; F22H5_4; homeobox protein 33; ZHD5; zinc-finger homeodomain 5
Summary
Encodes a zinc finger-homeodomain transcription factor ZHD5. Nuclear import and DNA binding of the ZHD5 transcription factor is modulated by a competitive peptide inhibitor MIF1 (AT1G74660).
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Genomic context

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See HB33 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_003070.9 (28241011..28242795)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase Neighboring gene Major facilitator superfamily protein Neighboring gene DNA glycosylase superfamily protein Neighboring gene RAD-like 6 Neighboring gene oxidoreductases, acting on NADH or NADPH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Auxin Response Factor2 (ARF2) and its regulated homeodomain gene HB33 mediate abscisic acid response in Arabidopsis. Wang L, et al. PLoS Genet, 2011 Jul. PMID 21779177, Free PMC Article
  2. Nuclear import and DNA binding of the ZHD5 transcription factor is modulated by a competitive peptide inhibitor in Arabidopsis. Hong SY, et al. J Biol Chem, 2011 Jan 14. PMID 21059647, Free PMC Article
  3. The Arabidopsis zinc finger-homeodomain genes encode proteins with unique biochemical properties that are coordinately expressed during floral development. Tan QK, et al. Plant Physiol, 2006 Mar. PMID 16428600, Free PMC Article
  4. Promoter-based integration in plant defense regulation. Li B, et al. Plant Physiol, 2014 Dec. PMID 25352272, Free PMC Article
  5. A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. Smit ME, et al. Plant Cell, 2020 Feb. PMID 31806676, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARF2 and HB33 are novel regulators in the abscissic acid signal pathway, which has crosstalk with auxin signal pathway in regulating plant growth.
    Title: Auxin Response Factor2 (ARF2) and its regulated homeodomain gene HB33 mediate abscisic acid response in Arabidopsis.
  2. observations indicate that MIF1 regulates the ZHD5 activities in a dual step manner: nuclear import and DNA binding. [ZHD5]
    Title: Nuclear import and DNA binding of the ZHD5 transcription factor is modulated by a competitive peptide inhibitor in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_106180.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
homeobox protein 33
NP_565106.1
  • homeobox protein 33 (HB33); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: cellular_component unknown; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox domain, ZF-HD class (InterPro:IPR006455), ZF-HD homeobox protein, Cys/His-rich dimerisation domain (InterPro:IPR006456), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox protein 24 (TAIR:AT2G18350.1); Has 705 Blast hits to 675 proteins in 76 species: Archae - 0; Bacteria - 8; Metazoa - 117; Fungi - 10; Plants - 549; Viruses - 3; Other Eukaryotes - 18 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    28241011..28242795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_106180.4 → NP_565106.1  homeobox protein 33 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565106.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FRL5
    UniProtKB/TrEMBL
    A0A178WFZ4, A0A5S9WUI2
    Conserved Domains (2) summary
    TIGR01565
    Location:240 → 296
    homeo_ZF_HD; homeobox domain, ZF-HD class
    pfam04770
    Location:73 → 127
    ZF-HD_dimer; ZF-HD protein dimerization region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FRL5.1

Gene LinkOut

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