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GTB1 global transcription factor group B1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842855, updated on 18-Sep-2024

Summary

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Official Symbol
GTB1
Official Full Name
global transcription factor group B1
Primary source
TAIR:AT1G65440
Locus tag
AT1G65440
See related
Araport:AT1G65440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
GLOBAL TRANSCRIPTION FACTOR GROUP B; global transcription factor group B1; T8F5.22; T8F5_22
Summary
Related to yeast Spt6 protein, which functions as part of a protein complex in transcription initiation and also plays a role in chromatin structure / assembly.
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Genomic context

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See GTB1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
18
Sequence:
Chromosome: 1; NC_003070.9 (24306545..24314639, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box/kelch-repeat protein Neighboring gene IBR domain-containing protein Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene chromatin assembly factor-1 (FASCIATA1) (FAS1)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis. Liu Y, et al. Nat Commun, 2024 May 25. PMID 38796517, Free PMC Article
  2. RNA polymerase II-independent recruitment of SPT6L at transcription start sites in Arabidopsis. Chen C, et al. Nucleic Acids Res, 2019 Jul 26. PMID 31127286, Free PMC Article
  3. SPT6L encoding a putative WG/GW-repeat protein regulates apical-basal polarity of embryo in Arabidopsis. Gu XL, et al. Mol Plant, 2012 Jan. PMID 21948524
  4. Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis. Shu J, et al. Nucleic Acids Res, 2022 Dec 9. PMID 36453990, Free PMC Article
  5. Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression. Li L, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20139304, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis.
    Title: A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis.
  2. Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis.
    Title: Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis.
  3. SPT6L plays its conserved role in facilitating RNAPII occupancy across transcribed genes. Its enrichment is unexpectedly shifted, from gene body to transcription start site (TSS), when its association with RNAPII is disrupted. The HtH and YqgF domains are required for the TSS association. Recruitment of SPT6L at TSS is indispensable for its spreading along the gene body during transcription. [SPT6L]
    Title: RNA polymerase II-independent recruitment of SPT6L at transcription start sites in Arabidopsis.
  4. SPT6L encoding a putative WG/GW-repeat protein regulates apical-basal polarity of embryo.
    Title: SPT6L encoding a putative WG/GW-repeat protein regulates apical-basal polarity of embryo in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001084306.2
NM_001198388.1
NM_001334206.1
NM_105218.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
global transcription factor group B1
NP_001077775.1
  • global transcription factor group B1 (GTB1); FUNCTIONS IN: transcription elongation regulator activity, hydrolase activity, acting on ester bonds, RNA binding; INVOLVED IN: chromatin assembly or disassembly, transcription initiation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Resolvase, RNase H-like fold (InterPro:IPR006641), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Transcription elongation factor Spt6 (InterPro:IPR017072); BEST Arabidopsis thaliana protein match is: Transcription elongation factor Spt6 (TAIR:AT1G63210.1); Has 59515 Blast hits to 32300 proteins in 2671 species: Archae - 146; Bacteria - 13496; Metazoa - 17051; Fungi - 6893; Plants - 5011; Viruses - 737; Other Eukaryotes - 16181 (source: NCBI BLink).
NP_001185317.1
  • global transcription factor group B1 (GTB1); FUNCTIONS IN: transcription elongation regulator activity, hydrolase activity, acting on ester bonds, RNA binding; INVOLVED IN: chromatin assembly or disassembly, transcription initiation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Resolvase, RNase H-like fold (InterPro:IPR006641), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Transcription elongation factor Spt6 (InterPro:IPR017072); BEST Arabidopsis thaliana protein match is: Transcription elongation factor Spt6 (TAIR:AT1G63210.1).
NP_176723.3
  • global transcription factor group B1 (GTB1); FUNCTIONS IN: transcription elongation regulator activity, hydrolase activity, acting on ester bonds, RNA binding; INVOLVED IN: chromatin assembly or disassembly, transcription initiation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Resolvase, RNase H-like fold (InterPro:IPR006641), Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), SH2 motif (InterPro:IPR000980), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Transcription elongation factor Spt6 (InterPro:IPR017072); BEST Arabidopsis thaliana protein match is: Transcription elongation factor Spt6 (TAIR:AT1G63210.1); Has 154550 Blast hits to 61131 proteins in 3458 species: Archae - 353; Bacteria - 39994; Metazoa - 50717; Fungi - 13479; Plants - 12820; Viruses - 1975; Other Eukaryotes - 35212 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    24306545..24314639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105218.5 → NP_176723.3  global transcription factor group B1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176723.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MS85, O80815, Q0WN83
    UniProtKB/TrEMBL
    A0A178W8K9, A0A5S9WS40
    Conserved Domains (11) summary
    smart00732
    Location:716 → 833
    YqgFc; Likely ribonuclease with RNase H fold
    smart00316
    Location:1102 → 1174
    S1; Ribosomal protein S1-like RNA-binding domain
    cd09918
    Location:1225 → 1313
    SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
    cd09928
    Location:1324 → 1410
    SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
    COG2183
    Location:320 → 1222
    Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
    pfam09371
    Location:340 → 568
    Tex_N; Tex-like protein N-terminal domain
    pfam14632
    Location:86 → 117
    SPT6_acidic; Acidic N-terminal SPT6
    pfam14633
    Location:1205 → 1409
    SH2_2; SH2 domain
    pfam14641
    Location:292 → 403
    HTH_44; Helix-turn-helix DNA-binding domain of SPT6
    pfam14878
    Location:991 → 1096
    DLD; Death-like domain of SPT6
    cl22429
    Location:875 → 975
    HHH_5; Helix-hairpin-helix domain

  2. NM_001198388.1 → NP_001185317.1  global transcription factor group B1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185317.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W8K9, A0A5S9WS40, F4I9Y9
    Conserved Domains (11) summary
    smart00732
    Location:687 → 804
    YqgFc; Likely ribonuclease with RNase H fold
    smart00316
    Location:1073 → 1145
    S1; Ribosomal protein S1-like RNA-binding domain
    cd09918
    Location:1196 → 1284
    SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
    cd09928
    Location:1295 → 1381
    SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
    COG2183
    Location:291 → 1193
    Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
    pfam09371
    Location:311 → 539
    Tex_N; Tex-like protein N-terminal domain
    pfam14632
    Location:57 → 88
    SPT6_acidic; Acidic N-terminal SPT6
    pfam14633
    Location:1176 → 1380
    SH2_2; SH2 domain
    pfam14641
    Location:263 → 374
    HTH_44; Helix-turn-helix DNA-binding domain of SPT6
    pfam14878
    Location:962 → 1067
    DLD; Death-like domain of SPT6
    cl22429
    Location:846 → 946
    HHH_5; Helix-hairpin-helix domain

  3. NM_001334206.1 → NP_001321759.1  global transcription factor group B1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MS85, O80815, Q0WN83
    UniProtKB/TrEMBL
    A0A178W8K9, A0A5S9WS40

  4. NM_001084306.2 → NP_001077775.1  global transcription factor group B1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077775.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W8K9, A0A5S9WS40, F4I9Y7
    Conserved Domains (11) summary
    smart00732
    Location:716 → 833
    YqgFc; Likely ribonuclease with RNase H fold
    smart00316
    Location:1102 → 1174
    S1; Ribosomal protein S1-like RNA-binding domain
    cd09918
    Location:1225 → 1313
    SH2_Nterm_SPT6_like; N-terminal Src homology 2 (SH2) domain found in Spt6
    cd09928
    Location:1324 → 1410
    SH2_Cterm_SPT6_like; C-terminal Src homology 2 (SH2) domain found in Spt6
    COG2183
    Location:320 → 1222
    Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
    pfam09371
    Location:340 → 568
    Tex_N; Tex-like protein N-terminal domain
    pfam14632
    Location:86 → 117
    SPT6_acidic; Acidic N-terminal SPT6
    pfam14633
    Location:1205 → 1409
    SH2_2; SH2 domain
    pfam14641
    Location:292 → 403
    HTH_44; Helix-turn-helix DNA-binding domain of SPT6
    pfam14878
    Location:991 → 1096
    DLD; Death-like domain of SPT6
    cl22429
    Location:875 → 975
    HHH_5; Helix-hairpin-helix domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MS85.1

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