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Hrd1B RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842812, updated on 18-Sep-2024

Summary

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Official Symbol
Hrd1B
Official Full Name
RING/U-box superfamily protein
Primary source
TAIR:AT1G65040
Locus tag
AT1G65040
See related
Araport:AT1G65040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtHrd1B; F16G16.3; F16G16_3; homolog of yeast Hrd1
Summary
Encodes one of the Arabidopsis homologs of the yeast/human Hrd1 protein: AT3G16090 (Hrd1A), AT1G65040 (Hrd1B). Involved in ERAD (Endoplasmic reticulum-associated degradation).
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Genomic context

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See Hrd1B in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Sequence:
Chromosome: 1; NC_003070.9 (24159685..24163669, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene WEB family protein (DUF827) Neighboring gene plasma protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene COMPLEX 1 LYR-like protein Neighboring gene TRAF-like superfamily protein Neighboring gene 4-coumarate:CoA ligase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis. Wu P, et al. Plant Physiol Biochem, 2021 Oct. PMID 34404006
  2. Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Su W, et al. Proc Natl Acad Sci U S A, 2011 Jan 11. PMID 21187394, Free PMC Article
  3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis.
    Title: Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis.
Submit: New GeneRIF Correction

General gene information

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NM_001084305.1
NM_001334186.1
NM_001334187.1
NM_105178.5
NM_179512.4

Gene Ontology Provided by TAIR

Process Evidence Code Pubs
acts_upstream_of_or_within ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
RING/U-box superfamily protein
NP_001077774.1
  • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: plasma membrane; EXPRESSED IN: male gametophyte, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G16090.1); Has 7753 Blast hits to 7726 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 2329; Fungi - 701; Plants - 3577; Viruses - 25; Other Eukaryotes - 1121 (source: NCBI BLink).
NP_176684.4
  • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: plasma membrane; EXPRESSED IN: male gametophyte, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G16090.1); Has 7722 Blast hits to 7710 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 2325; Fungi - 695; Plants - 3566; Viruses - 25; Other Eukaryotes - 1111 (source: NCBI BLink).
NP_849843.3
  • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: plasma membrane; EXPRESSED IN: male gametophyte, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G16090.1); Has 7762 Blast hits to 7743 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 2332; Fungi - 714; Plants - 3566; Viruses - 25; Other Eukaryotes - 1125 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    24159685..24163669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001334185.1 → NP_001322004.1  RING/U-box superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WKT8, A0A1P8ASM3, A0A5S9WSF5

  2. NM_179512.4 → NP_849843.3  RING/U-box superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849843.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3ECI3, Q6NPT7, Q9SS55
    UniProtKB/TrEMBL
    A0A178WKT8, A0A5S9WSF5
    Conserved Domains (2) summary
    COG5243
    Location:9 → 386
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    pfam13639
    Location:291 → 330
    zf-RING_2; Ring finger domain

  3. NM_001084305.1 → NP_001077774.1  RING/U-box superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077774.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WKT8, A0A5S9WSF5, B3H675
    Conserved Domains (2) summary
    COG5243
    Location:45 → 315
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    pfam13639
    Location:220 → 259
    zf-RING_2; Ring finger domain

  4. NM_001334186.1 → NP_001322005.1  RING/U-box superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ASN3

  5. NM_001334187.1 → NP_001322006.1  RING/U-box superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ASL9

  6. NM_105178.5 → NP_176684.4  RING/U-box superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176684.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27GM7
    Conserved Domains (1) summary
    pfam13639
    Location:112 → 151
    zf-RING_2; Ring finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NPT7.1

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