PEN3 ABC-2 and Plant PDR ABC-type transporter family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PEN3
Official Full Name: ABC-2 and Plant PDR ABC-type transporter family protein
Primary source: TAIR:AT1G59870
Locus tag: AT1G59870
See related: Araport:AT1G59870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABCG36; ARABIDOPSIS PLEIOTROPIC DRUG RESISTANCE 8; Arabidopsis thaliana ATP-binding cassette G36; ARABIDOPSIS THALIANA ATP-BINDING CASSETTE G36; ATABCG36; ATP-binding cassette G36; ATP-BINDING CASSETTE G36; ATPDR8; F23H11.19; F23H11_19; PDR8; PENETRATION 3; PLEIOTROPIC DRUG RESISTANCE 8
Summary: ATP binding cassette transporter. Localized to the plasma membrane in uninfected cells. In infected leaves, the protein concentrated at infection sites. Contributes to nonhost resistance to inappropriate pathogens that enter by direct penetration in a salicylic acid#Aeidependent manner. Required for mlo resistance. Has Cd transporter activity (Cd2+ extrusion pump) and contributes to heavy metal resistance.
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Genomic context

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See PEN3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (22034423..22040126)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pleiotropic drug resistance (PDR) transporter PENETRATION3 (PEN3)/PDR8 in Arabidopsis (Arabidopsis thaliana) has been implicated in resistance to a variety of fungal pathogens. The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea.
Title: The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea.
These results suggest that the MMDH2 gene negatively regulates cadmium (Cd) tolerance by modulating reactive oxygen species (ROS) levels and the ROS-mediated signaling, thus, affecting the expression of PDR8.
Title: Negative regulation of cadmium tolerance in Arabidopsis by MMDH2.
the Arabidopsis ENDOPLASMIC RETICULUM-ARRESTED PEN3 (EAP3) BTB/POZ-domain protein specifically mediates PEN3 exit from the endoplasmic reticulum and confers resistance to a root-penetrating fungus
Title: Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility.
ACTIN7 (ACT7) mediates trafficking of the PENETRATION3 (PEN3) outer membrane protein from the trans-Golgi network (TGN) to the plasma membrane in the root epidermis of Arabidopsis.
Title: A Framework for Lateral Membrane Trafficking and Polar Tethering of the PEN3 ATP-Binding Cassette Transporter.
CaM7 as a PEN3-interacting protein crucial to Arabidopsis Nonhost resistance (NHR) and emphasizes the importance of Ca(2+) sensing to plant immunity.
Title: ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance.
PEN3 transports distinct indole-type metabolites in distinct biological processes.
Title: Mutant Allele-Specific Uncoupling of PENETRATION3 Functions Reveals Engagement of the ATP-Binding Cassette Transporter in Distinct Tryptophan Metabolic Pathways.
existing PEN3 is redirected through an unknown trafficking pathway to sites of pathogen detection for export into papillae
Title: Perception of conserved pathogen elicitors at the plasma membrane leads to relocalization of the Arabidopsis PEN3 transporter.
These results indicate that PEN3 plays a positive role in plant resistance to a bacterial pathogen and show that focal accumulation of PEN3 protein may be a useful cellular response marker for the Arabidopsis-P. syringae interaction.
Title: Induction and suppression of PEN3 focal accumulation during Pseudomonas syringae pv. tomato DC3000 infection of Arabidopsis.
AtABCG36 contributes to drought and salt resistance in Arabidopsis by a mechanism that includes reduction of sodium content in plants. [ABCG36]
Title: Overexpression of AtABCG36 improves drought and salt stress resistance in Arabidopsis.
Data found that pdr8 mutants display defects in efflux of the auxin precursor IBA and developmental defects in root hair and cotyledon expansion that reveal previously unknown roles for IBA-derived IAA in plant growth and development.
Title: The Arabidopsis PLEIOTROPIC DRUG RESISTANCE8/ABCG36 ATP binding cassette transporter modulates sensitivity to the auxin precursor indole-3-butyric acid.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_104680.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ABC-type indole transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables auxin efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cadmium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cadmium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to indolebutyric acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to indolebutyric acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cotyledon development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coumarin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response by callose deposition in cell wall	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to oomycetes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in export from cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within indole glucosinolate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pathogen-associated molecular pattern receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of auxin mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defense response by callose deposition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lateral root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to chitin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fungus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to molecule of bacterial origin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to molecule of fungal origin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to molecule of fungal origin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to molecule of oomycetes origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oomycetes	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in root hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thymidine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
NOT located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast envelope	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ABC-2 and Plant PDR ABC-type transporter family protein

NP_176196.1

PENETRATION 3 (PEN3); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, cadmium ion transmembrane transporter activity; INVOLVED IN: in 9 processes; LOCATED IN: mitochondrion, plasma membrane, chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), Plant PDR ABC transporter associated (InterPro:IPR013581), ABC-2 type transporter (InterPro:IPR013525); BEST Arabidopsis thaliana protein match is: pleiotropic drug resistance 7 (TAIR:AT1G15210.1); Has 392230 Blast hits to 282257 proteins in 3986 species: Archae - 7583; Bacteria - 315608; Metazoa - 9692; Fungi - 7346; Plants - 6702; Viruses - 4; Other Eukaryotes - 45295 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

22034423..22040126

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104680.3 → NP_176196.1 ABC-2 and Plant PDR ABC-type transporter family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176196.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8VXW5, Q9XIE2

UniProtKB/TrEMBL

A0A178W9Z8, A0A5S9WQS1

Conserved Domains (6) summary

cd03232
Location:864 → 1102

ABCG_PDR_domain2; Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters

cd03233
Location:154 → 426

ABCG_PDR_domain1; First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters

PLN03140
Location:31 → 1469

PLN03140; ABC transporter G family member; Provisional

pfam01061
Location:1197 → 1404

ABC2_membrane; ABC-2 type transporter

pfam08370
Location:740 → 800

PDR_assoc; Plant PDR ABC transporter associated

pfam14510
Location:89 → 165

ABC_trans_N; ABC-transporter extracellular N-terminal