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ZIP4 Clathrin adaptor complexes medium subunit family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842113, updated on 18-Sep-2024

Summary

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Official Symbol
ZIP4
Official Full Name
Clathrin adaptor complexes medium subunit family protein
Primary source
TAIR:AT1G56590
Locus tag
AT1G56590
See related
Araport:AT1G56590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
adaptor protein-3 mu-adaptin; AP3M; F25P12.96; F25P12_96; ZIG SUPPRESSOR 4
Summary
Involved in vesicle trafficking between the trans -Golgi network and vacuoles.
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Genomic context

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See ZIP4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Sequence:
Chromosome: 1; NC_003070.9 (21201948..21204856, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Plant neutral invertase family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene plant/protein (Protein of unknown function, DUF538) Neighboring gene galactinol synthase 2 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis adaptor protein AP-3μ interacts with the G-protein β subunit AGB1 and is involved in abscisic acid regulation of germination and post-germination development. Kansup J, et al. J Exp Bot, 2013 Dec. PMID 24098050, Free PMC Article
  2. ZIP genes encode proteins involved in membrane trafficking of the TGN-PVC/vacuoles. Niihama M, et al. Plant Cell Physiol, 2009 Dec. PMID 19884248
  3. The ADAPTOR PROTEIN-3 Complex Mediates Pollen Tube Growth by Coordinating Vacuolar Targeting and Organization. Feng QN, et al. Plant Physiol, 2018 May. PMID 29523712, Free PMC Article
  4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
  5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role for AP-3 in pollen tube growth.
    Title: The ADAPTOR PROTEIN-3 Complex Mediates Pollen Tube Growth by Coordinating Vacuolar Targeting and Organization.
  2. At1g56590(AP-3micro) positively regulates the abscisic acid responses independently of AGB1 in seed germination, while AP-3micro does require AGB1 to regulate abscisic acid responses during post-germination growth.
    Title: The Arabidopsis adaptor protein AP-3μ interacts with the G-protein β subunit AGB1 and is involved in abscisic acid regulation of germination and post-germination development.
  3. zip4 is a loss-of-function mutant of a putative ortholog of the yeast AP-3 mu subunit, and is involved in protein trafficking between the trans-Golgi network and vacuoles.
    Title: ZIP genes encode proteins involved in membrane trafficking of the TGN-PVC/vacuoles.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_104536.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within gravitropism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein targeting to vacuole IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Clathrin adaptor complexes medium subunit family protein
NP_176052.3
  • ZIG SUPPRESSOR 4 (ZIP4); INVOLVED IN: intracellular protein transport, gravitropism, protein targeting to vacuole; LOCATED IN: clathrin vesicle coat, clathrin adaptor complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, mu subunit, conserved site (InterPro:IPR018240), Clathrin adaptor, mu subunit (InterPro:IPR001392), Clathrin adaptor, mu subunit, C-terminal (InterPro:IPR008968), Longin-like (InterPro:IPR011012); BEST Arabidopsis thaliana protein match is: Clathrin adaptor complexes medium subunit family protein (TAIR:AT1G60780.1); Has 1984 Blast hits to 1954 proteins in 323 species: Archae - 0; Bacteria - 0; Metazoa - 926; Fungi - 482; Plants - 226; Viruses - 0; Other Eukaryotes - 350 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    21201948..21204856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104536.5 → NP_176052.3  Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176052.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I562, Q9FXB1
    UniProtKB/TrEMBL
    A0A5S9WQ97, A0A654EP65
    Conserved Domains (2) summary
    cd09252
    Location:167 → 414
    AP-3_Mu3_Cterm; C-terminal domain of medium Mu3 subunit in adaptor protein (AP) complex AP-3
    cd14837
    Location:3 → 142
    AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4I562.1

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