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SERAT2;1 serine acetyltransferase 2;1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842043, updated on 18-Sep-2024

Summary

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Official Symbol
SERAT2;1
Official Full Name
serine acetyltransferase 2;1
Primary source
TAIR:AT1G55920
Locus tag
AT1G55920
See related
Araport:AT1G55920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATSERAT2;1; F14J16.18; F14J16_18; SAT1; SAT5; SERINE ACETYLTRANSFERASE; SERINE ACETYLTRANSFERASE 1; serine acetyltransferase 2;1; SERINE ACETYLTRANSFERASE 5
Summary
Encodes a chloroplast/cytosol localized serine O-acetyltransferase involved in sulfur assimilation and cysteine biosynthesis. Expressed in the vascular system.
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Genomic context

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See SERAT2;1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
1
Sequence:
Chromosome: 1; NC_003070.9 (20912116..20913565)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene zinc transporter 11 precursor Neighboring gene zinc ion binding protein Neighboring gene uncharacterized protein Neighboring gene nuclear speckle splicing regulatory-like protein (DUF2040) Neighboring gene CBS domain-containing protein / transporter associated domain-containing protein Neighboring gene cytochrome P450 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of serine acetlytransferase produced large increases in O-acetylserine and free cysteine in developing seeds of a grain legume. Tabe L, et al. J Exp Bot, 2010 Mar. PMID 19939888, Free PMC Article
  2. Serine acetyltransferase from Arabidopsis thaliana can functionally complement the cysteine requirement of a cysE mutant strain of Escherichia coli. Murillo M, et al. Cell Mol Biol Res, 1995. PMID 8867790
  3. Subcellular distribution of serine acetyltransferase from Pisum sativum and characterization of an Arabidopsis thaliana putative cytosolic isoform. Ruffet ML, et al. Eur J Biochem, 1995 Jan 15. PMID 7851429
  4. Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis. Park SW, et al. Proc Natl Acad Sci U S A, 2013 Jun 4. PMID 23671085, Free PMC Article
  5. Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis. Krueger S, et al. Plant Cell Environ, 2009 Apr. PMID 19143986

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression in developing lupin embryos of a serine acetyltransferase (SAT) from Arabidopsis thaliana (AtSAT1 or AtSerat 2;1) was associated with increases of up to 5-fold in the concentrations of O-acetylserine and up to 26-fold in free cysteine.
    Title: Overexpression of serine acetlytransferase produced large increases in O-acetylserine and free cysteine in developing seeds of a grain legume.
  2. Plastidic SERAT2;1 contributes less to OAS formation and subsequent Cys synthesis.
    Title: Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
  3. Cytosolic SERAT1.1 and plastidic SERAT2.1 do not contribute to cysteine biosynthesis.
    Title: Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis.
  4. Binding of the C-terminus of serine acetyltransferase by acetylserine sulfhydrylase contributes a large portion of the total binding energy during formation of the plant cysteine synthase complex.
    Title: Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase.
  5. From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
    Title: In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_104470.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine O-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine O-acetyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to sulfate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cysteine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
serine acetyltransferase 2;1
NP_175988.1
  • serine acetyltransferase 2;1 (SERAT2;1); FUNCTIONS IN: serine O-acetyltransferase activity; INVOLVED IN: cellular response to sulfate starvation, response to cold; LOCATED IN: cytosol, chloroplast, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Hexapeptide transferase, conserved site (InterPro:IPR018357), Serine O-acetyltransferase (InterPro:IPR005881), Trimeric LpxA-like (InterPro:IPR011004), Serine acetyltransferase, N-terminal (InterPro:IPR010493); BEST Arabidopsis thaliana protein match is: serine acetyltransferase 2;2 (TAIR:AT3G13110.1); Has 24449 Blast hits to 24415 proteins in 2638 species: Archae - 407; Bacteria - 18561; Metazoa - 8; Fungi - 223; Plants - 250; Viruses - 18; Other Eukaryotes - 4982 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    20912116..20913565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104470.3 → NP_175988.1  serine acetyltransferase 2;1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175988.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WT70, Q42588, Q43297
    UniProtKB/TrEMBL
    A0A178WQK2
    Conserved Domains (1) summary
    PLN02357
    Location:1 → 314
    PLN02357; serine acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q42588.2

Gene LinkOut

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