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UPL1 LOW protein: E3 ubiquitin ligase-like protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842036, updated on 18-Sep-2024

Summary

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Official Symbol
UPL1
Official Full Name
LOW protein: E3 ubiquitin ligase-like protein
Primary source
TAIR:AT1G55860
Locus tag
AT1G55860
See related
Araport:AT1G55860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F14J16.37; ubiquitin-protein ligase 1
Summary
encodes a ubiquitin-protein ligase containing a HECT domain. There are six other HECT-domain UPLs in Arabidopsis.
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Genomic context

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See UPL1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Sequence:
Chromosome: 1; NC_003070.9 (20879900..20893268, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene cellulose synthase like E1 Neighboring gene ncRNA Neighboring gene ubiquitin-protein ligase Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene Pyridoxal-5'-phosphate-dependent enzyme family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UPL1 and 2, two 405 kDa ubiquitin-protein ligases from Arabidopsis thaliana related to the HECT-domain protein family. Bates PW, et al. Plant J, 1999 Oct. PMID 10571878
  2. Protein degradation in signaling. Callis J, et al. Curr Opin Plant Biol, 2000 Oct. PMID 11019805
  3. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
  4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
  5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

NM_001198316.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasmodesma HDA PubMed 
part_of ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of ubiquitin ligase complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
LOW protein: E3 ubiquitin ligase-like protein
NP_001185245.1
  • ubiquitin-protein ligase 1 (UPL1); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: cytosol, mitochondrion, ubiquitin ligase complex, membrane; EXPRESSED IN: guard cell, cultured cell, trichome, leaf; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), E3 ubiquitin ligase, domain of unknown function DUF913 (InterPro:IPR010314), HECT (InterPro:IPR000569), Ubiquitin interacting motif (InterPro:IPR003903), E3 ubiquitin ligase, domain of unknown function DUF908 (InterPro:IPR010309), Armadillo-type fold (InterPro:IPR016024), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: ubiquitin-protein ligase 2 (TAIR:AT1G70320.1); Has 8980 Blast hits to 7230 proteins in 418 species: Archae - 33; Bacteria - 397; Metazoa - 4053; Fungi - 1646; Plants - 643; Viruses - 68; Other Eukaryotes - 2140 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    20879900..20893268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198316.2 → NP_001185245.1  LOW protein: E3 ubiquitin ligase-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185245.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I1Y3, Q8GY23, Q9LG27, Q9M7K7
    UniProtKB/TrEMBL
    A0A178WHZ8
    Conserved Domains (6) summary
    smart00119
    Location:3343 → 3678
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:3319 → 3679
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14327
    Location:1273 → 1310
    UBA_atUPL1_2_like; UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 (atUPL2) and similar proteins
    pfam06012
    Location:88 → 358
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:416 → 763
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2609 → 2704
    DUF4414; Domain of unknown function (DUF4414)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GY23.3

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