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POLGAMMA2 polymerase gamma 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841506, updated on 18-Sep-2024

Summary

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Official Symbol
POLGAMMA2
Official Full Name
polymerase gamma 2
Primary source
TAIR:AT1G50840
Locus tag
AT1G50840
See related
Araport:AT1G50840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F8A12.8; F8A12_8; PolIA; polymerase gamma 2; polymerase I A
Summary
DNA Polymerase gamma2. Dual targeting to mitochondria and plastids due to alternative translation initiation.
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Genomic context

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See POLGAMMA2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (18839047..18844577)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene aminotransferase-like, mobile domain protein Neighboring gene pseudo Neighboring gene Aminotransferase-like, plant mobile domain family protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Participation of leaky ribosome scanning in protein dual targeting by alternative translation initiation in higher plants. Wamboldt Y, et al. Plant Cell, 2009 Jan. PMID 19182105, Free PMC Article
  2. Identification of a unique insertion in plant organellar DNA polymerases responsible for 5'-dRP lyase and strand-displacement activities: Implications for Base Excision Repair. Trasviña-Arenas CH, et al. DNA Repair (Amst), 2018 May. PMID 29522990
  3. Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases. Baruch-Torres N, et al. Nucleic Acids Res, 2017 Oct 13. PMID 28977655, Free PMC Article
  4. Divergent roles for the two PolI-like organelle DNA polymerases of Arabidopsis. Parent JS, et al. Plant Physiol, 2011 May. PMID 21427281, Free PMC Article
  5. Arabidopsis thaliana organelles mimic the T7 phage DNA replisome with specific interactions between Twinkle protein and DNA polymerases Pol1A and Pol1B. Morley SA, et al. BMC Plant Biol, 2019 Jun 6. PMID 31170927, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction of Twinkle with Pol1A or Pol1B mimics the minimal DNA replisomes of T7 phage and those present in mammalian mitochondria. However, while T7 and mammals absolutely require their homolog of Twinkle DNA helicase-primase, Arabidopsis Twinkle mutants are seemingly unaffected by this loss.
    Title: Arabidopsis thaliana organelles mimic the T7 phage DNA replisome with specific interactions between Twinkle protein and DNA polymerases Pol1A and Pol1B.
  2. PolIA & PolIB are functionally equipped to play a role in short-patch BER and suggest a major role of PolIA & PolIB in a predicted long-patch base excision repair (BER) sub-pathway. We propose that the acquisition of insertion 1 in the polymerization domain of PolIA & PolIB was a key component in their evolution as BER associated and replicative DNA polymerases.
    Title: Identification of a unique insertion in plant organellar DNA polymerases responsible for 5'-dRP lyase and strand-displacement activities: Implications for Base Excision Repair.
  3. both AtPolIA and AtPolIB are efficient translesion DNA synthesis polymerases, providing the first example of a family-A DNAP with an active exonuclease domain that efficiently bypasses an AP site.
    Title: Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases.
  4. Alternative translation initiation in Polgamma2 involves leaky ribosome scanning of both cis- and trans-acting components.
    Title: Participation of leaky ribosome scanning in protein dual targeting by alternative translation initiation in higher plants.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_103965.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plastid DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plastid IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
polymerase gamma 2
NP_175498.2
  • polymerase gamma 2 (POLGAMMA2); FUNCTIONS IN: DNA binding, DNA-directed DNA polymerase activity; INVOLVED IN: DNA replication, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-directed DNA polymerase, family A, palm domain (InterPro:IPR001098), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA polymerase A domain (InterPro:IPR002298), 3'-5' exonuclease (InterPro:IPR002562); BEST Arabidopsis thaliana protein match is: polymerase gamma 1 (TAIR:AT3G20540.1); Has 11974 Blast hits to 10011 proteins in 2572 species: Archae - 0; Bacteria - 6712; Metazoa - 149; Fungi - 0; Plants - 122; Viruses - 286; Other Eukaryotes - 4705 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    18839047..18844577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001333457.1 → NP_001321058.1  polymerase gamma 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APQ6, A0A5S9WNC2

  2. NM_103965.5 → NP_175498.2  polymerase gamma 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175498.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I6M1, Q8W105, Q9C6J5
    UniProtKB/TrEMBL
    A0A5S9WNC2
    Conserved Domains (3) summary
    cd08640
    Location:639 → 1048
    DNA_pol_A_plastid_like; DNA polymerase A type from plastids of higher plants possibly involve in DNA replication or in the repair of errors occurring during replication
    cd06139
    Location:290 → 523
    DNA_polA_I_Ecoli_like_exo; DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases
    COG0749
    Location:305 → 1050
    PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4I6M1.1

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