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HKL1 hexokinase-like 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841468, updated on 18-Sep-2024

Summary

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Official Symbol
HKL1
Official Full Name
hexokinase-like 1
Primary source
TAIR:AT1G50460
Locus tag
AT1G50460
See related
Araport:AT1G50460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATHKL1; F11F12.18; F11F12_18; hexokinase-like 1
Summary
Involved in glucose-ethylene crosstalk.
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Genomic context

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See HKL1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (18693644..18697709)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Saccharopine dehydrogenase Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene 10-formyltetrahydrofolate synthetase Neighboring gene ubiquitin-conjugating enzyme 20

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth. Karve A, et al. J Exp Bot, 2009. PMID 19706780, Free PMC Article
  2. Arabidopsis Hexokinase-Like1 and Hexokinase1 form a critical node in mediating plant glucose and ethylene responses. Karve A, et al. Plant Physiol, 2012 Apr. PMID 22366209, Free PMC Article
  3. Isozymes of plant hexokinase: occurrence, properties and functions. Claeyssen E, et al. Phytochemistry, 2007 Mar. PMID 17234224
  4. Functional analysis of the Hikeshi-like protein and its interaction with HSP70 in Arabidopsis. Koizumi S, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24942879
  5. Expression and evolutionary features of the hexokinase gene family in Arabidopsis. Karve A, et al. Planta, 2008 Aug. PMID 18481082, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HKL1 and HXK1 can interact, these two proteins likely form a critical node in Glc signaling that mediates overlapping, but also distinct, cellular responses to Glc and ethylene treatments.
    Title: Arabidopsis Hexokinase-Like1 and Hexokinase1 form a critical node in mediating plant glucose and ethylene responses.
  2. hexokinase-like1 acts as a negative regulator of plant growth.
    Title: Function of Arabidopsis hexokinase-like1 as a negative regulator of plant growth.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001333439.1
NM_103929.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables fructokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables glucokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within root hair cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
hexokinase-like 1
NP_175463.1
  • hexokinase-like 1 (HKL1); FUNCTIONS IN: hexokinase activity, ATP binding; INVOLVED IN: response to salt stress, response to cold, response to osmotic stress; LOCATED IN: mitochondrion, plastid; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Hexokinase, N-terminal (InterPro:IPR022672), Hexokinase, C-terminal (InterPro:IPR022673), Hexokinase (InterPro:IPR001312); BEST Arabidopsis thaliana protein match is: Hexokinase (TAIR:AT3G20040.1); Has 2396 Blast hits to 2128 proteins in 324 species: Archae - 0; Bacteria - 92; Metazoa - 1286; Fungi - 598; Plants - 287; Viruses - 0; Other Eukaryotes - 133 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    18693644..18697709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001333438.1 → NP_001322009.1  hexokinase-like 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ASN0

  2. NM_103929.4 → NP_175463.1  hexokinase-like 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175463.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LPS1
    UniProtKB/TrEMBL
    A0A178W513, A0A5S9WNI8
    Conserved Domains (1) summary
    PLN02362
    Location:1 → 498
    PLN02362; hexokinase

  3. NM_001333439.1 → NP_001322008.1  hexokinase-like 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ASQ8, A0A7G2DZZ5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LPS1.1

Gene LinkOut

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