U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HCS2 holocarboxylase synthetase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840632, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
HCS2
Official Full Name
holocarboxylase synthetase 2
Primary source
TAIR:AT1G37150
Locus tag
AT1G37150
See related
Araport:AT1G37150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F28L22.1; F28L22_1; holocarboxylase synthetase 2
Summary
Although HCS2 is predicted to encode a biotin protein ligase / holocarboxylase synthetase (HCS), hcs2 mutants do not show a decrease in HCS activity. A dual-targeted HCS1 (At2g25710) might account for the HCS activity observed in multiple subcellular compartments in Arabidopsis.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HCS2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (14174798..14178034, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene nitrate reductase 2 Neighboring gene MEI2 C-terminal RRM only like 1 Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dual targeting of Arabidopsis holocarboxylase synthetase1: a small upstream open reading frame regulates translation initiation and protein targeting. Puyaubert J, et al. Plant Physiol, 2008 Feb. PMID 18156294, Free PMC Article
  2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help
NM_001333187.1
NM_001333188.1
NM_001333189.1
NM_001333190.1
NM_001333191.1
NM_103366.3
NM_180625.1
NM_180626.2
NM_180627.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables biotin--[biotin carboxyl-carrier protein] ligase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables biotin--[biotin carboxyl-carrier protein] ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
holocarboxylase synthetase 2
NP_174903.3
  • holocarboxylase synthetase 2 (HCS2); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: pedicel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Biotin protein ligase, C-terminal (InterPro:IPR003142), Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthase 1 (TAIR:AT2G25710.2); Has 6001 Blast hits to 6001 proteins in 2273 species: Archae - 223; Bacteria - 3976; Metazoa - 118; Fungi - 132; Plants - 62; Viruses - 0; Other Eukaryotes - 1490 (source: NCBI BLink).
NP_850956.1
  • holocarboxylase synthetase 2 (HCS2); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: pedicel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthase 1 (TAIR:AT2G25710.2); Has 5973 Blast hits to 5971 proteins in 2277 species: Archae - 223; Bacteria - 3992; Metazoa - 119; Fungi - 132; Plants - 61; Viruses - 0; Other Eukaryotes - 1446 (source: NCBI BLink).
NP_850957.1
  • holocarboxylase synthetase 2 (HCS2); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: pedicel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Biotin protein ligase, C-terminal (InterPro:IPR003142), Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthase 1 (TAIR:AT2G25710.2); Has 6007 Blast hits to 6005 proteins in 2275 species: Archae - 225; Bacteria - 3982; Metazoa - 119; Fungi - 134; Plants - 60; Viruses - 0; Other Eukaryotes - 1487 (source: NCBI BLink).
NP_850958.1
  • holocarboxylase synthetase 2 (HCS2); FUNCTIONS IN: biotin-[acetyl-CoA-carboxylase] ligase activity, catalytic activity; INVOLVED IN: protein modification process; EXPRESSED IN: pedicel; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Biotin/lipoate A/B protein ligase (InterPro:IPR004143), Biotin--acetyl-CoA-carboxylase ligase (InterPro:IPR004408); BEST Arabidopsis thaliana protein match is: holocarboxylase synthase 1 (TAIR:AT2G25710.2); Has 6049 Blast hits to 6045 proteins in 2294 species: Archae - 225; Bacteria - 4030; Metazoa - 120; Fungi - 134; Plants - 62; Viruses - 0; Other Eukaryotes - 1478 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    14174798..14178034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180627.2 → NP_850958.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850958.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WP99
    Conserved Domains (2) summary
    COG0340
    Location:82 → 280
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam03099
    Location:78 → 206
    BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

  2. NM_001333188.1 → NP_001320615.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WP99, A0A1P8ANC7

  3. NM_001333187.1 → NP_001320614.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WP99, A0A1P8ANC7

  4. NM_001333189.1 → NP_001320613.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WP99

  5. NM_001333190.1 → NP_001320616.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WP99

  6. NM_001333191.1 → NP_001320617.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WP99, A0A1P8AND5

  7. NM_103366.3 → NP_174903.3  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174903.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4I4W1, Q8S4V6
    Conserved Domains (3) summary
    COG0340
    Location:39 → 278
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam02237
    Location:225 → 279
    BPL_C; Biotin protein ligase C terminal domain
    pfam03099
    Location:37 → 163
    BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

  8. NM_180626.2 → NP_850957.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850957.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I4W2, Q8S4V5, Q8S4V7, Q9SHR6
    UniProtKB/TrEMBL
    A0A5S9WM69, A0A654EFN7
    Conserved Domains (3) summary
    COG0340
    Location:82 → 321
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam02237
    Location:268 → 322
    BPL_C; Biotin protein ligase C terminal domain
    pfam03099
    Location:78 → 206
    BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family

  9. NM_180625.1 → NP_850956.1  holocarboxylase synthetase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850956.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8S4V3, Q8S4V4
    Conserved Domains (2) summary
    COG0340
    Location:11 → 197
    BirA2; Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]
    pfam03099
    Location:1 → 123
    BPL_LplA_LipB; Biotin/lipoate A/B protein ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4I4W2.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.