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ADR1 Disease resistance protein (CC-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840250, updated on 18-Sep-2024

Summary

Official Symbol
ADR1
Official Full Name
Disease resistance protein (CC-NBS-LRR class) family
Primary source
TAIR:AT1G33560
Locus tag
AT1G33560
See related
Araport:AT1G33560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ACTIVATED DISEASE RESISTANCE 1; F10C21.19
Summary
Encodes a NBS-LRR disease resistance protein that possesses N-terminal kinase subdomains. Activation tagged mutant of ADR1 showed elevated levels of SA and reactive oxygen species in addition to number of defense gene transcripts. Exhibits resistance to number of microbial pathogens.
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Genomic context

See ADR1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (12168768..12172119)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene serine carboxypeptidase-like 18 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

NM_103079.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP binding  
enables kinase activity PubMed 
Component Evidence Code Pubs
is_active_in cellular_component  

General protein information

Preferred Names
Disease resistance protein (CC-NBS-LRR class) family
NP_174620.2
  • ACTIVATED DISEASE RESISTANCE 1 (ADR1); FUNCTIONS IN: kinase activity; INVOLVED IN: response to water deprivation, response to karrikin, response to other organism, defense response; LOCATED IN: endomembrane system; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Powdery mildew resistance protein, RPW8 domain (InterPro:IPR008808), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: ADR1-like 2 (TAIR:AT5G04720.1); Has 17381 Blast hits to 12089 proteins in 491 species: Archae - 20; Bacteria - 813; Metazoa - 875; Fungi - 81; Plants - 15224; Viruses - 0; Other Eukaryotes - 368 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    12168768..12172119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103079.4 → NP_174620.2  Disease resistance protein (CC-NBS-LRR class) family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174620.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FW44
    UniProtKB/TrEMBL
    Q0WQR8
    Conserved Domains (3) summary
    sd00033
    Location:602 → 632
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00931
    Location:173 → 414
    NB-ARC; NB-ARC domain
    pfam05659
    Location:10 → 117
    RPW8; Arabidopsis broad-spectrum mildew resistance protein RPW8
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