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GTL1 GT-2-like 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840218, updated on 18-Sep-2024

Summary

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Official Symbol
GTL1
Official Full Name
GT-2-like 1
Primary source
TAIR:AT1G33240
Locus tag
AT1G33240
See related
Araport:AT1G33240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AT-GTL1; AT-GTL2; ATGTL1; GT-2-like 1; GT2-LIKE 1; GT2-LIKE 2; T9L6.10; T9L6_10
Summary
Encodes a plant transcriptional activator that contains two separate, but similar, trihelix DNA-binding domains, similar to GT-2. Gene is expressed in all aerial parts of the plant, with higher level of expression in siliques. At-GTL2 was thought to be a duplicated copy of this gene but is likely to be a cloning artefact, the result of a chimeric clone. Regulates ploidy-dependent cell growth in trichome.
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Genomic context

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See GTL1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (12051361..12054753, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene TMPIT-like protein Neighboring gene miscRNA Neighboring gene beta-1,3-n-acetylglucosaminyltransferase radical fringe protein, putative (DUF604)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional repression of the APC/C activator CCS52A1 promotes active termination of cell growth. Breuer C, et al. EMBO J, 2012 Dec 12. PMID 23143274, Free PMC Article
  2. The trihelix transcription factor GTL1 regulates ploidy-dependent cell growth in the Arabidopsis trichome. Breuer C, et al. Plant Cell, 2009 Aug. PMID 19717615, Free PMC Article
  3. The trihelix DNA-binding motif in higher plants is not restricted to the transcription factors GT-1 and GT-2. Smalle J, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501260, Free PMC Article
  4. GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis. Shibata M, et al. Development, 2018 Feb 8. PMID 29439132, Free PMC Article
  5. Regulation of stomatal density by the GTL1 transcription factor for improving water use efficiency. Yoo CY, et al. Plant Signal Behav, 2011 Jul. PMID 21691149, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A trihelix transcription factor GT-2-LIKE1 (GTL1) and its homolog DF1 repress root hair growth. Transcriptional data, combined with genome-wide chromatin-binding data, show that GTL1 and DF1 directly bind the RSL4 promoter and regulate its expression to repress root hair growth.
    Title: GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis.
  2. GTL1 actively terminates ploidy-dependent cell growth and its developmentally regulated expression is one of the key determinants of cell size in Arabidopsis leaf hair cells (trichomes).
    Title: Transcriptional repression of the APC/C activator CCS52A1 promotes active termination of cell growth.
  3. Data identified Arabidopsis GT2-LIKE 1 (GTL1) as a transcriptional repressor of STOMATAL DENSITY AND DISTRIBUTION 1 (SDD1), a negative regulator of stomatal density.
    Title: Regulation of stomatal density by the GTL1 transcription factor for improving water use efficiency.
  4. Study provides the genetic evidence for the requirement of transcriptional regulation in the repression of ploidy-dependent plant cell growth as well as for an involvement of GTL trihelix proteins in this regulation.
    Title: The trihelix transcription factor GTL1 regulates ploidy-dependent cell growth in the Arabidopsis trichome.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001333032.1
NM_103052.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of stomatal complex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of stomatal complex patterning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within trichome morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
GT-2-like 1
NP_174594.1
  • GT-2-like 1 (GTL1); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), MYB-like (InterPro:IPR017877); BEST Arabidopsis thaliana protein match is: Duplicated homeodomain-like superfamily protein (TAIR:AT1G76890.2); Has 6156 Blast hits to 4698 proteins in 415 species: Archae - 8; Bacteria - 243; Metazoa - 2333; Fungi - 696; Plants - 1321; Viruses - 126; Other Eukaryotes - 1429 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    12051361..12054753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001333031.1 → NP_001322395.1  GT-2-like 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WCI5, A0A1P8ATX4

  2. NM_103052.4 → NP_174594.1  GT-2-like 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174594.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WCI5
    Conserved Domains (1) summary
    cd12203
    Location:435 → 499
    GT1; myb-like, SANT family

  3. NM_001333032.1 → NP_001322396.1  GT-2-like 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O48590, O48591, Q7FPN7, Q8L6Y5, Q9C882, Q9LP25
    UniProtKB/TrEMBL
    A0A1P8ATZ4
Nucleotide Protein
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