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APL2 ADPGLC-PPase large subunit [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839660, updated on 18-Sep-2024

Summary

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Official Symbol
APL2
Official Full Name
ADPGLC-PPase large subunit
Primary source
TAIR:AT1G27680
Locus tag
AT1G27680
See related
Araport:AT1G27680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ADPGLC-PPase large subunit; T22C5.13; T22C5_13
Summary
ADP-glucose pyrophosphorylase catalyzes the first, rate limiting step in starch biosynthesis. The large subunit plays a regulatory role whereas the small subunit (ApS) is the catalytic isoform. Four isoforms of the large subunit (ApL1-4) have been described.Mutational analysis of APS1 suggests that APL1 and APL2 can compensate for loss of APS1 catalytic activity,suggesting both have catalytic as well as regulatory functions.
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Genomic context

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See APL2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (9631190..9634597)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene lipase, putative (DUF620) Neighboring gene glycine-rich protein Neighboring gene Syntaxin/t-SNARE family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The different large subunit isoforms of Arabidopsis thaliana ADP-glucose pyrophosphorylase confer distinct kinetic and regulatory properties to the heterotetrameric enzyme. Crevillén P, et al. J Biol Chem, 2003 Aug 1. PMID 12748181
  2. Sugars and light/dark exposure trigger differential regulation of ADP-glucose pyrophosphorylase genes in Arabidopsis thaliana (thale cress). Sokolov LN, et al. Biochem J, 1998 Dec 15. PMID 9841881, Free PMC Article
  3. Molecular characterization of multiple cDNA clones for ADP-glucose pyrophosphorylase from Arabidopsis thaliana. Villand P, et al. Plant Mol Biol, 1993 Dec. PMID 8292792
  4. Two Arabidopsis ADP-glucose pyrophosphorylase large subunits (APL1 and APL2) are catalytic. Ventriglia T, et al. Plant Physiol, 2008 Sep. PMID 18614708, Free PMC Article
  5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. may contribute to ADP-glucose synthesis
    Title: Two Arabidopsis ADP-glucose pyrophosphorylase large subunits (APL1 and APL2) are catalytic.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_102533.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables glucose-1-phosphate adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose-1-phosphate adenylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in starch biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within starch biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
ADPGLC-PPase large subunit
NP_174089.1
  • ADPGLC-PPase large subunit (APL2); CONTAINS InterPro DOMAIN/s: Glucose-1-phosphate adenylyltransferase (InterPro:IPR011831), ADP-glucose pyrophosphorylase, conserved site (InterPro:IPR005836), Nucleotidyl transferase (InterPro:IPR005835); BEST Arabidopsis thaliana protein match is: Glucose-1-phosphate adenylyltransferase family protein (TAIR:AT4G39210.1); Has 11860 Blast hits to 11712 proteins in 2161 species: Archae - 516; Bacteria - 8154; Metazoa - 62; Fungi - 36; Plants - 1704; Viruses - 0; Other Eukaryotes - 1388 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    9631190..9634597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102533.5 → NP_174089.1  ADPGLC-PPase large subunit [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174089.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55230, Q9SFZ1
    UniProtKB/TrEMBL
    A0A178W595, A0A5S9W3A4
    Conserved Domains (1) summary
    PLN02241
    Location:82 → 518
    PLN02241; glucose-1-phosphate adenylyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55230.2

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