HK3 histidine kinase 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HK3
Official Full Name: histidine kinase 3
Primary source: TAIR:AT1G27320
Locus tag: AT1G27320
See related: Araport:AT1G27320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AHK3; F17L21.11; F17L21_11; histidine kinase 3
Summary: Encodes a histidine kinases, a cytokinin receptor that controls cytokinin-mediated leaf longevity through a specific phosphorylation of the response regulator, ARR2.
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Genomic context

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See HK3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 11

Sequence:: Chromosome: 1; NC_003070.9 (9486889..9492632)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AHK3-mediated cytokinin signaling is required for the delayed leaf senescence caused by SSPP overexpression and the detailed mechanism remains to be further elucidated.
Title: AHK3-Mediated Cytokinin Signaling Is Required for the Delayed Leaf Senescence Induced by SSPP.
Cytokinins promote actin bundling and the resultant second rapid cell elongation through activating the signaling pathway involving the cytokinin receptors ARABIDOPSIS HISTIDINE KINASE3 (AHK3) and AHK4 and the B-type transcription factor ARABIDOPSIS RESPONSE REGULATOR2.
Title: Actin Reorganization Triggers Rapid Cell Elongation in Roots.
Data show that the gain-of-function alleles of cytokinin receptors AHK2 and AHK3 have an impact on cytokinin homeostasis and lower the cytokinin content, suggesting a feedback regulation of cytokinin metabolism by the cytokinin signaling pathway.
Title: Gain-of-Function Mutants of the Cytokinin Receptors AHK2 and AHK3 Regulate Plant Organ Size, Flowering Time and Plant Longevity.
Data indicate that accumulation of transcripts of several plastid-encoded genes is dependent on the capital A, Cyrilliccapital EN, Cyrilliccapital KA, Cyrillic2/capital A, Cyrilliccapital EN, Cyrilliccapital KA, Cyrillic3 receptor combination.
Title: Opposite roles of the Arabidopsis cytokinin receptors AHK2 and AHK3 in the expression of plastid genes and genes for the plastid transcriptional machinery during senescence.
Study suggests that the key role in the regulation of expression of the studied plastome genes by cytokinin in etiolated Arabidopsis plants is played by the AHK3 receptor, whereas AHK4 and AHK2 receptors cannot regulate this process
Title: Cytokinin membrane receptors participate in regulation of plastid genome expression in the skotomorphogenesis.
The AHK2/AHK3-Dependent Two-Component Signaling System Causes Ser/Thr/Tyr Phosphorylation and Dephosphorylation in Arabidopsis thaliana
Title: The Sensor Histidine Kinases AHK2 and AHK3 Proceed into Multiple Serine/Threonine/Tyrosine Phosphorylation Pathways in Arabidopsis thaliana.
The cytokinin module ARABIDOPSIS HISTIDINE KINASE3 (AHK3)/ARABIDOPSIS RESPONSE REGULATOR1 (ARR1)/ARR12 was found to interact with the GR24-dependent reduction in LR development, because mutants in this pathway rendered LR development insensitive to GR24.
Title: Strigolactones spatially influence lateral root development through the cytokinin signaling network.
Results show the stress physiology function of histidine kinaseS AHK2, AHK3 AND AHK4.
Title: Stress physiology functions of the Arabidopsis histidine kinase cytokinin receptors.
The role of the histidine kinases AHK2 and AHK3 in light- and abscisic acid-mediated stomatal aperture control.
Title: Involvement of two-component signalling systems in the regulation of stomatal aperture by light in Arabidopsis thaliana.
the protective function of cytokinin during light stress depends on the Arabidopsis histidine KINASE2 (AHK2) and AHK3 receptors.
Title: A novel protective function for cytokinin in the light stress response is mediated by the Arabidopsis histidine kinase2 and Arabidopsis histidine kinase3 receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_102494.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cytokinin receptor activity	TAS Traceable Author Statement more info	PubMed
enables osmosensor activity	IGI Inferred from Genetic Interaction more info	PubMed
NOT enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay sensor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein histidine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein histidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein histidine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to abscisic acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to phosphate starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to sucrose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokinin-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phloem or xylem histogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of chlorophyll catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meristem development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of seed germination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of shoot system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed
involved_in secondary growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histidine kinase 3

NP_564276.1

histidine kinase 3 (HK3); CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CHASE (InterPro:IPR006189), Signal transduction histidine kinase, core (InterPro:IPR005467), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: histidine kinase 2 (TAIR:AT5G35750.1); Has 124308 Blast hits to 110912 proteins in 3043 species: Archae - 772; Bacteria - 110408; Metazoa - 31; Fungi - 2185; Plants - 2022; Viruses - 28; Other Eukaryotes - 8862 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

9486889..9492632

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102494.4 → NP_564276.1 histidine kinase 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564276.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C5U1, Q9FZK3

UniProtKB/TrEMBL

A0A178WL02, A0A654EEU4

Conserved Domains (2) summary

PRK11107
Location:441 → 1036

PRK11107; hybrid sensory histidine kinase BarA; Provisional

pfam03924
Location:165 → 362

CHASE; CHASE domain