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MC1 metacaspase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839561, updated on 18-Sep-2024

Summary

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Official Symbol
MC1
Official Full Name
metacaspase 1
Primary source
TAIR:AT1G02170
Locus tag
AT1G02170
See related
Araport:AT1G02170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA METACASPASE 1; ARABIDOPSIS THALIANA METACASPASE 1B; ATMC1; AtMCP1b; ATMCPB1; LOL3; LSD ONE LIKE 3; MCP1b; MCP1B; metacaspase 1; metacaspase 1b; T6A9.24
Summary
Encodes a type I metacaspase. Two Arabidopsis metacaspases, AT1G02170 (MC1) and AT4G25110 (MC2) antagonistically control programmed cell death in Arabidopsis. MC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. MC2 negatively regulates cell death. This function is independent of the putative catalytic residues. A third type I Arabidopsis metacaspase is MC3 (AT5g64240).
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Genomic context

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See MC1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (411664..413554)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Cox19 family protein (CHCH motif) Neighboring gene ferredoxin-like protein Neighboring gene Fatty acid hydroxylase superfamily Neighboring gene Fatty acid hydroxylase superfamily

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy. Coll NS, et al. Cell Death Differ, 2014 Sep. PMID 24786830, Free PMC Article
  2. AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta. Lema Asqui S, et al. New Phytol, 2018 May. PMID 28157265
  3. Arabidopsis type I metacaspases control cell death. Coll NS, et al. Science, 2010 Dec 3. PMID 21097903
  4. Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. Watanabe N, et al. J Biol Chem, 2005 Apr 15. PMID 15691845
  5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtSerpin1 blocked AtMC1 self-processing and inhibited AtMC1-mediated cell death.
    Title: AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta.
  2. This novel pro-survival role of AtMC1 may be functionally related to its prodomain-mediated aggregate localization and potential clearance, in agreement with recent findings using the single budding yeast metacaspase YCA1.
    Title: The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy.
  3. study shows type I metacaspases, AtMC1 and AtMC2, antagonistically control programmed cell death; AtMC1 is a positive regulator of cell death; requires conserved caspase-like putative catalytic residues for function; AtMC2 negatively regulates cell death
    Title: Arabidopsis type I metacaspases control cell death.
  4. AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases with roles in apoptosis. [AtMCP1b]
    Title: Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_100097.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
metacaspase 1
NP_171719.2
  • metacaspase 1 (AMC1); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: proteolysis, induction of apoptosis; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735), Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 2 (TAIR:AT4G25110.1); Has 1179 Blast hits to 1148 proteins in 266 species: Archae - 3; Bacteria - 262; Metazoa - 3; Fungi - 268; Plants - 419; Viruses - 0; Other Eukaryotes - 224 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    411664..413554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100097.5 → NP_171719.2  metacaspase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171719.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81911, Q7XJE6
    UniProtKB/TrEMBL
    A0A178W8H4, A0A5S9S592, A0A654EGQ5
    Conserved Domains (2) summary
    TIGR01053
    Location:15 → 45
    LSD1; zinc finger domain, LSD1 subclass
    pfam00656
    Location:80 → 316
    Peptidase_C14; Caspase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7XJE6.1

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