HCAR coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HCAR
Official Full Name: coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family
Primary source: TAIR:AT1G04620
Locus tag: AT1G04620
See related: Araport:AT1G04620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 7-hydroxymethyl chlorophyll a (HMChl) reductase; T1G11.13; T1G11_13
Summary: Encodes a 7-hydroxymethyl chlorophyll a reductase, an enzyme of the chlorophyll cycle that converts 7-hydroxymethyl chlorophyll a to chlorophyll a.
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Genomic context

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See HCAR in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 19

Sequence:: Chromosome: 1; NC_003070.9 (1282163..1286619, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpressing 7-Hydroxymethyl Chlorophyll a Reductase Alleviates Non-Programmed Cell Death during Dark-Induced Senescence in Intact Arabidopsis Plants.
Title: Overexpressing 7-Hydroxymethyl Chlorophyll a Reductase Alleviates Non-Programmed Cell Death during Dark-Induced Senescence in Intact Arabidopsis Plants.
HCAR Is a Limitation Factor for Chlorophyll Cycle and Chlorophyll b Degradation in Chlorophyll-b-Overproducing Plants.
Title: HCAR Is a Limitation Factor for Chlorophyll Cycle and Chlorophyll b Degradation in Chlorophyll-b-Overproducing Plants.
addition to functioning in the conversion of 7-HMC a to Chl a in senescent leaves, HCAR may play a critical role in protecting plants from high light-induced damage by preventing the accumulation of 7-HMC a and Pheo a in developing and mature leaves at the vegetative stage
Title: Rice 7-Hydroxymethyl Chlorophyll a Reductase Is Involved in the Promotion of Chlorophyll Degradation and Modulates Cell Death Signaling.
report the crystal structure of Arabidopsis HCAR at 2.7-A resolution and reveal that two [4Fe-4S]clusters and one FAD within a very short distance form a consecutive electron pathway to the substrate pocket. In vitro kinetic analysis confirms the ferredoxin-dependent electron transport chain, thus supporting a proton-activated electron transfer mechanism.
Title: Crystal Structure and Catalytic Mechanism of 7-Hydroxymethyl Chlorophyll a Reductase.
in Arabidopsis, 7-hydroxymethyl chlorophyll a reductase overexpressing plants exhibited accelerated leaf yellowing and, conversely, hcar mutants stayed green during dark-induced senescence.
Title: 7-Hydroxymethyl chlorophyll a reductase functions in metabolic channeling of chlorophyll breakdown intermediates during leaf senescence.
7-hydroxymethyl chlorophyll a reductase contains flavin adenine dinucleotide and an iron-sulfur center. It converts 7-hydroxymethyl chlorophyll a to chlorophyll a using ferredoxin.
Title: Identification of the 7-hydroxymethyl chlorophyll a reductase of the chlorophyll cycle in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_100341.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 7-hydroxymethyl chlorophyll a reductase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chlorophyll cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chlorophyll metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in extracellular region	HDA more info	PubMed

General protein information

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Preferred Names: coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family

NP_171956.2

coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family; FUNCTIONS IN: coenzyme F420 hydrogenase activity; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal (InterPro:IPR007525), Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal (InterPro:IPR007516); Has 499 Blast hits to 498 proteins in 165 species: Archae - 202; Bacteria - 188; Metazoa - 0; Fungi - 0; Plants - 41; Viruses - 0; Other Eukaryotes - 68 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

1282163..1286619 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100341.4 → NP_171956.2 coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171956.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O23023, Q8GS60

UniProtKB/TrEMBL

A0A178W7H4

Conserved Domains (1) summary

cl27156
Location:56 → 358

FrhB_FdhB_C; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C-terminus