WEE1 WEE1-like kinase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: WEE1
Official Full Name: WEE1-like kinase
Primary source: TAIR:AT1G02970
Locus tag: AT1G02970
See related: Araport:AT1G02970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATWEE1; F22D16.3; F22D16_3; WEE1 kinase homolog; WEE1-KINASE
Summary: Protein kinase that negatively regulates the entry into mitosis.
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Genomic context

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See WEE1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 10

Sequence:: Chromosome: 1; NC_003070.9 (673306..676419)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Buying time: FASCIATA1 deficiency rescues wee1 plants from replication stress by delaying mitosis.
Title: Buying time: FASCIATA1 deficiency rescues wee1 plants from replication stress by delaying mitosis.
G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.
Title: G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.
The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response.
Title: The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response.
Expression of Arabidopsis WEE1 in tobacco induces unexpected morphological and developmental changes.
Title: Expression of Arabidopsis WEE1 in tobacco induces unexpected morphological and developmental changes.
the identification of a second member of the RNase H2 complex, RNase H2B, being able to complement the root growth phenotype of WEE1(KO) plants, is reported.
Title: Lack of RNase H2 activity rescues HU-sensitivity of WEE1 deficient plants.
mutant alleles of the genes encoding subunits of the ribonuclease H2 (RNase H2) complex, known for its role in removing ribonucleotides from DNA-RNA duplexes, were identified as suppressor mutants of WEE1 knockout plants.
Title: Arabidopsis thaliana RNase H2 deficiency counteracts the needs for the WEE1 checkpoint kinase but triggers genome instability.
The plant WEE1 kinase acquired an indirect developmental function that is important for meristem maintenance upon replication stress.
Title: The Arabidopsis thaliana checkpoint kinase WEE1 protects against premature vascular differentiation during replication stress.
The WEE1 gene is not rate-limiting for cell cycle progression under normal growth conditions but is a critical target of the ATR-ATM signaling cascades that inhibit the cell cycle upon activation of the DNA integrity checkpoints.
Title: Arabidopsis WEE1 kinase controls cell cycle arrest in response to activation of the DNA integrity checkpoint.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_100178.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell cycle G2/M phase transition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: WEE1-like kinase

NP_171796.1

WEE1 kinase homolog (WEE1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT4G19110.2); Has 100256 Blast hits to 98965 proteins in 4396 species: Archae - 165; Bacteria - 12308; Metazoa - 39873; Fungi - 10996; Plants - 18240; Viruses - 408; Other Eukaryotes - 18266 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

673306..676419

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100178.3 → NP_171796.1 WEE1-like kinase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171796.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L4H0, Q9SRY9

UniProtKB/TrEMBL

A0A654E6H8

Conserved Domains (2) summary

smart00220
Location:249 → 495

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13997
Location:248 → 493

PKc_Wee1_like; Catalytic domain of the Wee1-like Protein Kinases