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AN NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839401, updated on 18-Sep-2024

Summary

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Official Symbol
AN
Official Full Name
NAD(P)-binding Rossmann-fold superfamily protein
Primary source
TAIR:AT1G01510
Locus tag
AT1G01510
See related
Araport:AT1G01510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ANGUSTIFOLIA; DETORQUEO; DOQ; F22L4.6; F22L4_6
Summary
Encodes a homolog of human CtBP. Mutant has longer and thicker leaves than wild type. Involved in controlling polar cell expansion in the leaf width direction.
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Genomic context

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Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (187145..190472)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Erythronate-4-phosphate dehydrogenase family protein Neighboring gene Homeodomain-like superfamily protein Neighboring gene AGAMOUS-like 28 Neighboring gene Protein kinase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cell morphogenesis ANGUSTIFOLIA (AN) gene, a plant homolog of CtBP/BARS, is involved in abiotic and biotic stress response in higher plants. Gachomo EW, et al. BMC Plant Biol, 2013 May 14. PMID 23672620, Free PMC Article
  2. Two independent and polarized processes of cell elongation regulate leaf blade expansion in Arabidopsis thaliana (L.) Heynh. Tsuge T, et al. Development, 1996 May. PMID 8625845
  3. Tissue layer specific regulation of leaf length and width in Arabidopsis as revealed by the cell autonomous action of ANGUSTIFOLIA. Bai Y, et al. Plant J, 2010 Jan. PMID 19843316
  4. ANGUSTIFOLIA, a plant homolog of CtBP/BARS, functions outside the nucleus. Minamisawa N, et al. Plant J, 2011 Dec. PMID 21801251
  5. ANGUSTIFOLIA, a Plant Homolog of CtBP/BARS Localizes to Stress Granules and Regulates Their Formation. Bhasin H, et al. Front Plant Sci, 2017. PMID 28659951, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis C-terminal binding protein ANGUSTIFOLIA modulates transcriptional co-regulation of MYB46 and WRKY33.
    Title: Arabidopsis C-terminal binding protein ANGUSTIFOLIA modulates transcriptional co-regulation of MYB46 and WRKY33.
  2. Two ANGUSTIFOLIA genes regulate gametophore and sporophyte development in Physcomitrella patens.
    Title: Two ANGUSTIFOLIA genes regulate gametophore and sporophyte development in Physcomitrella patens.
  3. ANGUSTIFOLIA (AN) and ACTIN7 regulate centripetal nuclear positioning in Arabidopsis (Arabidopsis thaliana) leaves.
    Title: ANGUSTIFOLIA Regulates Actin Filament Alignment for Nuclear Positioning in Leaves.
  4. These results suggest that the AN protein is one of the critical downstream factors of SCM pathways specifically responsible for mediating its effects on cell/tissue morphogenesis through cortical microtubule arrangement.
    Title: ANGUSTIFOLIA mediates one of the multiple SCRAMBLED signaling pathways regulating cell growth pattern in Arabidopsis thaliana.
  5. ANGUSTIFOLIA participates in controlling cell morphogenesis, abiotic, and biotic stress responses.
    Title: The cell morphogenesis ANGUSTIFOLIA (AN) gene, a plant homolog of CtBP/BARS, is involved in abiotic and biotic stress response in higher plants.
  6. ANGUSTIFOLIA is a central component of tissue morphogenesis mediated by the atypical receptor-like kinase STRUBBELIG.
    Title: ANGUSTIFOLIA is a central component of tissue morphogenesis mediated by the atypical receptor-like kinase STRUBBELIG.
  7. Data show that subepidermal rescue of leaf width is accompanied by increased cell number in the epidermis, indicating that AN can trigger cell divisions in a non-autonomous manner.
    Title: Tissue layer specific regulation of leaf length and width in Arabidopsis as revealed by the cell autonomous action of ANGUSTIFOLIA.
  8. These data, taken together, suggest that AN is functionally distinct from dCtBP.
    Title: Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_100033.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cotyledon morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in floral organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fruit morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inductive cell-cell signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monopolar cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of epidermal cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of trichome morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trichome branching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NAD(P)-binding Rossmann-fold superfamily protein
NP_563629.1
  • ANGUSTIFOLIA (AN); CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-isomer specific 2-hydroxyacid dehydrogenase family protein (TAIR:AT1G12550.1); Has 20556 Blast hits to 20427 proteins in 2617 species: Archae - 372; Bacteria - 13694; Metazoa - 624; Fungi - 929; Plants - 529; Viruses - 5; Other Eukaryotes - 4403 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    187145..190472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100033.3 → NP_563629.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563629.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O03984, O23702, Q7DLS3, Q93YQ6, Q948X7, Q9LMM9
    UniProtKB/TrEMBL
    A0A178WFD8, A0A5S9S348, A0A654EAX4
    Conserved Domains (1) summary
    cd05299
    Location:21 → 339
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O23702.1

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