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Tic20-I translocon at the inner envelope membrane of chloroplasts 20 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839374, updated on 18-Sep-2024

Summary

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Official Symbol
Tic20-I
Official Full Name
translocon at the inner envelope membrane of chloroplasts 20
Primary source
TAIR:AT1G04940
Locus tag
AT1G04940
See related
Araport:AT1G04940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
atTIC20; AtTic20-I; F13M7.7; F13M7_7; TIC20; translocon at the inner envelope membrane of chloroplasts 20; translocon at the inner envelope membrane of chloroplasts 20-I
Summary
Tic20 is believed to function as a component of the protein-conducting channel at the inner envelope membrane. Genes AT1G04940 and AT1G04945 were switched for the TAIR7 genome release to give consistency with MIPs annotation. The Arabidopsis genome encodes four Tic20 homologous proteins, AT1G04940(Tic20-I), AT2G47840(Tic20-II), AT4G03320(Tic20-IV) and AT5G55710(Tic20-V).
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Genomic context

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See Tic20-I in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (1399182..1400830)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene sucrose phosphate synthase 3F Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene HIT-type Zinc finger family protein Neighboring gene TATA BOX ASSOCIATED FACTOR II 59 Neighboring gene golgin family A protein (DUF1664)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Folding and self-association of atTic20 in lipid membranes: implications for understanding protein transport across the inner envelope membrane of chloroplasts. Campbell JH, et al. BMC Biochem, 2014 Dec 31. PMID 25551276, Free PMC Article
  2. Molecular and genetic analyses of Tic20 homologues in Arabidopsis thaliana chloroplasts. Kasmati AR, et al. Plant J, 2011 Jun. PMID 21395885
  3. Tic20 forms a channel independent of Tic110 in chloroplasts. Kovács-Bogdán E, et al. BMC Plant Biol, 2011 Sep 30. PMID 21961525, Free PMC Article
  4. In vivo studies on the roles of two closely related Arabidopsis Tic20 proteins, AtTic20-I and AtTic20-IV. Hirabayashi Y, et al. Plant Cell Physiol, 2011 Mar. PMID 21266460
  5. Uncovering the protein translocon at the chloroplast inner envelope membrane. Kikuchi S, et al. Science, 2013 Feb 1. PMID 23372012

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. atTic20 functions similarly to other small alpha-helical integral membrane proteins, such as Tim23, that are involved in protein transport across membranes.
    Title: Folding and self-association of atTic20 in lipid membranes: implications for understanding protein transport across the inner envelope membrane of chloroplasts.
  2. Tic20 protein is much less abundant than Tic110 in envelope membranes. Tic20 forms high molecular weight complexes separately from Tic110.
    Title: Tic20 forms a channel independent of Tic110 in chloroplasts.
  3. The inner envelope localized Tic20 proteins expose their C-termini to the chloroplast stroma.
    Title: The localization of Tic20 proteins in Arabidopsis thaliana is not restricted to the inner envelope membrane of chloroplasts.
  4. AtTic20-IV is expressed mainly in roots whereas AtTic20-I is more abundant in shoots than in roots.
    Title: In vivo studies on the roles of two closely related Arabidopsis Tic20 proteins, AtTic20-I and AtTic20-IV.
  5. The tic20-I mutants exhibit albinism and severe defects in chloroplast biogenesis.
    Title: Molecular and genetic analyses of Tic20 homologues in Arabidopsis thaliana chloroplasts.
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General gene information

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NM_100372.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein import into chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein import into chloroplast stroma IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
translocon at the inner envelope membrane of chloroplasts 20
NP_171986.3
  • translocon at the inner envelope membrane of chloroplasts 20 (TIC20); CONTAINS InterPro DOMAIN/s: Uncharacterised conserved protein ycf60 (InterPro:IPR019109), Chloroplast protein import component Tic20 (InterPro:IPR005691); BEST Arabidopsis thaliana protein match is: HIT-type Zinc finger family protein (TAIR:AT1G04945.3); Has 279 Blast hits to 278 proteins in 76 species: Archae - 0; Bacteria - 100; Metazoa - 0; Fungi - 0; Plants - 114; Viruses - 0; Other Eukaryotes - 65 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1399182..1400830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100372.5 → NP_171986.3  translocon at the inner envelope membrane of chloroplasts 20 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171986.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GZ79, Q9MAU2
    UniProtKB/TrEMBL
    A0A178W3W6, A0A654E6U2
    Conserved Domains (1) summary
    cl15935
    Location:59 → 274
    TIC20; Chloroplast import apparatus Tic20-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GZ79.1

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