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PCS2 phytochelatin synthase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839354, updated on 18-Sep-2024

Summary

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Official Symbol
PCS2
Official Full Name
phytochelatin synthase 2
Primary source
TAIR:AT1G03980
Locus tag
AT1G03980
See related
Araport:AT1G03980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPCS2; F21M11.9; F21M11_9; phytochelatin synthase 2
Summary
Encodes a protein with phytochelatin synthase activity which binds Cd2+ and Cd-glutathione complexes with high affinity. The protein has been postulated to be involved in Cd2+ tolerance. AtPCS2 expression appears to be less than that of AtPCS1, explaining the inability of endogenous AtPCS2 to substitute for AtPCS1 in the cad1-3 mutant (AtPCS1 null).
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Genomic context

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See PCS2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Sequence:
Chromosome: 1; NC_003070.9 (1019311..1022108, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Calcium-binding EF hand family protein Neighboring gene ncRNA Neighboring gene G-box binding factor 4 Neighboring gene PAK-box/P21-Rho-binding family protein Neighboring gene Long-chain fatty alcohol dehydrogenase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of phytochelatin synthase AtPCS2 enhances salt tolerance in Arabidopsis thaliana. Kim YO, et al. J Plant Physiol, 2019 Sep. PMID 31357099
  2. Arabidopsis thaliana phytochelatin synthase 2 is constitutively active in vivo and can rescue the growth defect of the PCS1-deficient cad1-3 mutant on Cd-contaminated soil. Kühnlenz T, et al. J Exp Bot, 2014 Aug. PMID 24821959, Free PMC Article
  3. Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase. Romanyuk ND, et al. Plant Physiol, 2006 Jul. PMID 16714405, Free PMC Article
  4. Expression of Arabidopsis phytochelatin synthase 2 is too low to complement an AtPCS1-defective Cad1-3 mutant. Lee S, et al. Mol Cells, 2005 Feb 28. PMID 15750344
  5. Arabidopsis thaliana expresses a second functional phytochelatin synthase. Cazalé AC, et al. FEBS Lett, 2001 Oct 26. PMID 11684101

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis transcription factor WRKY45 confers cadmium tolerance via activating PCS1 and PCS2 expression.
    Title: Arabidopsis transcription factor WRKY45 confers cadmium tolerance via activating PCS1 and PCS2 expression.
  2. AtPCS2 plays a positive role in seed germination and seedling growth under salt stress through a series of indirect effects that are likely involved in H2O2 scavenging, regulation of osmotic adjustment and ion homeostasis.
    Title: Overexpression of phytochelatin synthase AtPCS2 enhances salt tolerance in Arabidopsis thaliana.
  3. Constitutive AtPCS2-dependent phytochelatin synthesis suggests a physiological role of AtPCS2 other than metal detoxification.
    Title: Arabidopsis thaliana phytochelatin synthase 2 is constitutively active in vivo and can rescue the growth defect of the PCS1-deficient cad1-3 mutant on Cd-contaminated soil.
  4. expression of AtPCS2 is weak compared to AtPCS1 in both roots and shoots of transgenic Arabidopsis; it was not capable of fully complementing the AtPCS1-defective cad1-3 mutant for cadmium resistance
    Title: Expression of Arabidopsis phytochelatin synthase 2 is too low to complement an AtPCS1-defective Cad1-3 mutant.
  5. papain Cys protease superfamily member which contains an auxiliary metal-sensing C-terminal domain that undergoes secondary gamma-Glu-Cys acylation
    Title: Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase.
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Pathways from PubChem

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General gene information

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Homology

NM_001331453.1
NM_001331455.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables glutathione gamma-glutamylcysteinyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione gamma-glutamylcysteinyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phytochelatin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phytochelatin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to metal ion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
phytochelatin synthase 2
NP_001318916.1
  • phytochelatin synthase 2 (PCS2); CONTAINS InterPro DOMAIN/s: Phytochelatin synthase, C-terminal (InterPro:IPR015407), Phytochelatin synthase (InterPro:IPR007719); BEST Arabidopsis thaliana protein match is: phytochelatin synthase 1 (PCS1) (TAIR:AT5G44070.1); Has 342 Blast hits to 342 proteins in 145 species: Archae - 0; Bacteria - 138; Metazoa - 36; Fungi - 7; Plants - 117; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1019311..1022108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100279.5 → NP_171894.1  phytochelatin synthase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171894.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZWB7
    UniProtKB/TrEMBL
    A0A178WLT1, A0A5S9SI26
    Conserved Domains (2) summary
    pfam05023
    Location:7 → 212
    Phytochelatin; Phytochelatin synthase
    pfam09328
    Location:230 → 433
    Phytochelatin_C; Domain of unknown function (DUF1984)

  2. NM_001331454.1 → NP_001322971.1  phytochelatin synthase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AVN4

  3. NM_001331453.1 → NP_001318916.1  phytochelatin synthase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2H1ZEA1

  4. NM_001331455.1 → NP_001322970.1  phytochelatin synthase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AVJ0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZWB7.1

Gene LinkOut

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