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BARD1 breast cancer associated RING 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839329, updated on 18-Sep-2024

Summary

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Official Symbol
BARD1
Official Full Name
breast cancer associated RING 1
Primary source
TAIR:AT1G04020
Locus tag
AT1G04020
See related
Araport:AT1G04020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATBARD1; breast cancer associated RING 1; F21M11.4; F21M11_4; ROW1
Summary
Encodes a protein containing two tandem BRCA1 C-Terminal (BRCT) domains, which function in phosphorylation-dependent protein#Aeiprotein interactions.Loss of function mutations cause defects in meristem organization due to failure to repress WUS. BARD1 binds to WUS promoter and over expression of BARD reduces the extent of WUS expression.
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Genomic context

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See BARD1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Sequence:
Chromosome: 1; NC_003070.9 (1036493..1040262)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene phospholipid sterol acyl transferase 1 Neighboring gene eisosome protein Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants. Jiao Y, et al. Sci China Life Sci, 2016 Aug. PMID 27502904
  2. ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells. Zhang Y, et al. Nat Commun, 2015 Jan 29. PMID 25631790, Free PMC Article
  3. A homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plants. Reidt W, et al. EMBO J, 2006 Sep 20. PMID 16957774, Free PMC Article
  4. Mutation of Arabidopsis BARD1 causes meristem defects by failing to confine WUSCHEL expression to the organizing center. Han P, et al. Plant Cell, 2008 Jun. PMID 18591352, Free PMC Article
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings suggest that the study of AtROW1 in plant may provide a model for elucidating the functional mechanism of BARD1 in mammals.
    Title: Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants.
  2. ROW1 is essential for quiescent centre maintenance and for stem cell niche development through the repression of WOX5 in the proximal meristem.
    Title: ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells.
  3. Data suggest that BARD1 regulates shoot apical meristem organization and maintenance by limiting WUS expression to the organizing center.
    Title: Mutation of Arabidopsis BARD1 causes meristem defects by failing to confine WUSCHEL expression to the organizing center.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001331456.1
NM_202029.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of meristem structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
breast cancer associated RING 1
NP_001318917.1
  • breast cancer associated RING 1 (BARD1); FUNCTIONS IN: transcription coactivator activity, DNA binding; INVOLVED IN: DNA repair, regulation of meristem structural organization, leaf development; LOCATED IN: intracellular; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, PHD-type (InterPro:IPR001965), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: breast cancer susceptibility1 (TAIR:AT4G21070.1); Has 5889 Blast hits to 5527 proteins in 313 species: Archae - 0; Bacteria - 10; Metazoa - 4435; Fungi - 374; Plants - 570; Viruses - 11; Other Eukaryotes - 489 (source: NCBI BLink).
NP_973758.2
  • breast cancer associated RING 1 (BARD1); FUNCTIONS IN: transcription coactivator activity, DNA binding; INVOLVED IN: DNA repair, regulation of meristem structural organization, leaf development; LOCATED IN: intracellular; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, PHD-type (InterPro:IPR001965), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: breast cancer susceptibility1 (TAIR:AT4G21070.1); Has 6045 Blast hits to 5706 proteins in 320 species: Archae - 0; Bacteria - 47; Metazoa - 4577; Fungi - 362; Plants - 542; Viruses - 11; Other Eukaryotes - 506 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1036493..1040262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001331456.1 → NP_001318917.1  breast cancer associated RING 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5A7D6, B5A7D7, F4I443, Q9ZWC2
    UniProtKB/TrEMBL
    A0A178W540, A0A2H1ZEA6, A0A384KH31
    Conserved Domains (4) summary
    TIGR00599
    Location:35 → 262
    rad18; DNA repair protein rad18
    cd15571
    Location:359 → 449
    ePHD; Extended plant homeodomain (PHD) finger, characterized by Cys2HisCys5HisCys2His
    cd17720
    Location:601 → 707
    BRCT_Bard1_rpt2; second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins
    cd17734
    Location:490 → 569
    BRCT_Bard1_rpt1; first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins

  2. NM_202029.2 → NP_973758.2  breast cancer associated RING 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973758.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5A7D6, B5A7D7, F4I443, Q9ZWC2
    UniProtKB/TrEMBL
    F4I442
    Conserved Domains (5) summary
    smart00292
    Location:599 → 703
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:491 → 564
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    TIGR00599
    Location:35 → 262
    rad18; DNA repair protein rad18
    cd15571
    Location:359 → 449
    ePHD; Extended plant homeodomain (PHD) finger, characterized by Cys2HisCys5HisCys2His
    pfam13639
    Location:34 → 63
    zf-RING_2; Ring finger domain
Nucleotide Protein
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